{"id":16893,"date":"2018-03-09T09:04:43","date_gmt":"2018-03-09T09:04:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-diosmina-y-hesperidina-en-la-fase-aguda-y-cronica-de-la-colitis-experimental-inducida-por-tnbs-en-ratas\/"},"modified":"2018-03-09T09:04:43","modified_gmt":"2018-03-09T09:04:43","slug":"efecto-de-diosmina-y-hesperidina-en-la-fase-aguda-y-cronica-de-la-colitis-experimental-inducida-por-tnbs-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-diosmina-y-hesperidina-en-la-fase-aguda-y-cronica-de-la-colitis-experimental-inducida-por-tnbs-en-ratas\/","title":{"rendered":"Efecto de diosmina y hesperidina en la fase aguda y cr\u00f3nica de la colitis experimental inducida por tnbs en ratas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leticia Banqueri Bueno <\/strong><\/h2>\n<p>En la presente tesis abordamos la posible actividad de los flavonoides hesperidina y diosmina sobre la enfermedad inflamatorio intestinal (eii), teniendo en cuenta que en los \u00faltimos a\u00f1os ha aumentado de forma significativa el n\u00famero de casos diagn\u00f3sticados y, que por otra pate, no se ha encontrado un f\u00e1rmaco que sea eficaz y est\u00e9 desprovisto de efectos adversos. La elecci\u00f3n de los flavonoides se hizo por:  a,- su actividad antioxidante  b,- ser mol\u00e9culas de f\u00e1cil obtenci\u00f3n a partir del pericarpio de los frutos del g\u00e9nero citrus  c,- sus escasos efectos secundarios  se proponen dos protocolos experimentales: uno de inflamaci\u00f3n intestinal aguda para ver el efecto preventivo y oro de inflamaci\u00f3n intestinal cr\u00f3nica para constatar el posible efecto regenerador de la mucosa intestinal.  las conclusiones son las siguientes:  la diosmina a dosis de 10 mg\/kg, previene el proceso intestinal agudo inducido por 10 mg de tnbs. \u00e9Ste efecto se puede justificar por su acci\u00f3n antioxidante y por la inhibici\u00f3n en la s\u00edntesis de ltb4.  la hesperidina, a dosis de 10 y 25 mg\/kg manifiesta efecto preventivo frente a la inflamaci\u00f3n aguda, debido a su acci\u00f3n antioxidante y a su capacidad normalizadora del transporte de fluidos y electrolitos.  la asociaci\u00f3n hesperidina\/diosmina (25\/10) mg\/kg, acelera la regeneraci\u00f3n de la musoca col\u00f3nica da\u00f1ada por 30 mg de tnbs, hecho que se puso de manifiesto mediante ensayos macrosc\u00f3picos, microsc\u00f3picos y bioqu\u00edmicos. El efecto regenerador se atribuye a la actuaci\u00f3n sin\u00e9rgica de ambos flavonoides por:  * acci\u00f3n antioxidante de hesperidina y disomina.  * inhibici\u00f3n de la s\u00edntesis de ltb4 por diosmina.  * inhibici\u00f3n de la s\u00edntesis de il-1beta debido a la hesperidina.  el efecto antioxidante de diosmina y hesperidina se debe a sus respectivas geninas (diosmetina y hesperetina), si bien az\u00facar resulta imprescindible, en su papel de transportador, para hacer posible la llegada a la g<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de diosmina y hesperidina en la fase aguda y cr\u00f3nica de la colitis experimental inducida por tnbs en ratas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de diosmina y hesperidina en la fase aguda y cr\u00f3nica de la colitis experimental inducida por tnbs en ratas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leticia Banqueri Bueno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Zarzuelo Zurita<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Jim\u00e9nez mart\u00edn <\/li>\n<li>Ana isabel Nieto ruiz de z\u00e1rate (vocal)<\/li>\n<li>Manuel Lamela gonz\u00e1lez (vocal)<\/li>\n<li>Mar\u00eda  Jos\u00e9 Montero g\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leticia Banqueri Bueno En la presente tesis abordamos la posible actividad de los flavonoides hesperidina y diosmina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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