{"id":16897,"date":"2018-03-09T09:04:43","date_gmt":"2018-03-09T09:04:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-citotoxicidad-natural-de-los-leucocitos-de-dorada-sparus-aurata-l\/"},"modified":"2018-03-09T09:04:43","modified_gmt":"2018-03-09T09:04:43","slug":"modulacion-de-la-citotoxicidad-natural-de-los-leucocitos-de-dorada-sparus-aurata-l","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/modulacion-de-la-citotoxicidad-natural-de-los-leucocitos-de-dorada-sparus-aurata-l\/","title":{"rendered":"Modulaci\u00f3n de la citotoxicidad natural de los leucocitos de dorada (sparus aurata l.)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alberto Cuesta Pe\u00f1afiel <\/strong><\/h2>\n<p>En la presente tesis doctoral se ha estudiado la respuesta citot\u00f3xica natural de los leucocitos de dorada (sparus aurata l.) Frente a c\u00e9lulas tumorales, siendo cuantificada mediante citometr\u00eda de flujo. As\u00ed mismo, se ha modulado y estudiado la expresi\u00f3n del ligando de fas (fasl) y del receptor de las c\u00e9lulas citot\u00f3xicas naturales (nccrp-1). Adem\u00e1s, hemos estimado el par\u00e1metro cin\u00e9tico velocidad m\u00e1xima de lisis durante dichas respuesta citot\u00f3xica.  la actividad citot\u00f3xica de los leucocitos, es detectada a partir de 10 min., Y resulta ser mayor para los leucocitos de ri\u00f1\u00f3n cef\u00e1lico que para los del exudado peritoneal, bazo o sangre. La velocidad m\u00e1xima de lisis de las c\u00e9lulas tumorales l-1210 es mayor que las de las k562.  los leucocitos de dorada expresan constitutivamente fasl citoplasm\u00e1tico, pero no en la membrana. Tambi\u00e9n expresan el nccrp-1.  la actividad citot\u00f3xica de los leucocitos de ri\u00f1\u00f3n cef\u00e1lico de dorada fue casi siempre mayor tras su tratamiento in vitro o in vivo con diferentes inmunomoduladores naturales tales como vitaminas (c, e, a), quitina, factor activador de macr\u00f3fagos, levaduras o con el inmunomodulador sint\u00e9tico levamisol, dependiendo de la concentraci\u00f3n y tiempo ensayado. El tratamiento in vivo mediante inyecci\u00f3n intraperioneal de vitamina a o quitina tambi\u00e9n aument\u00f3 considerablemente dicha actividad. Por el contrario, los factores de estr\u00e9s ensayados (cara elevada, anestesia e hipoxia) no producen un efecto inhibitorio importante sobre dicha respuesta citot\u00f3xica.  en definitiva, podemos afirmar que la actividad citot\u00f3xica natural de los leucocitos de dorada es una reacci\u00f3n r\u00e1pida en la que est\u00e1 implicada una poblaci\u00f3n heterog\u00e9nea de leucocitos formada por linfocitos, manocitos\/macr\u00f3fagos y granulocitos acid\u00f3filos. Dicha reacci\u00f3n podr\u00eda ser llevada a cabo con la intervenci\u00f3n de las mol\u00e9culas fasl y nccrp-1. Esta actividad se ve estimulada con la presencia de sustancias n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la citotoxicidad natural de los leucocitos de dorada (sparus aurata l.)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la citotoxicidad natural de los leucocitos de dorada (sparus aurata l.) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alberto Cuesta Pe\u00f1afiel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Meseguer Pe\u00f1alver<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Madrid perez <\/li>\n<li>Mar\u00eda del pilar Garc\u00eda pe\u00f1arrubia (vocal)<\/li>\n<li>liliana Jaso friedmann (vocal)<\/li>\n<li>pilar L\u00f3pez fierro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alberto Cuesta Pe\u00f1afiel En la presente tesis doctoral se ha estudiado la respuesta citot\u00f3xica natural de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,494,35,515,848,9399,1737,20868,2612,8235],"tags":[53153,8343,9826,53154,8670,36030],"class_list":["post-16897","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-agrarias","category-ciencias-de-la-vida","category-ciencias-veterinarias","category-citologia","category-cultivo-celular","category-inmunologia","category-inmunologia-veterinaria","category-inmunoquimica","category-murcia","tag-alberto-cuesta-penafiel","tag-jose-meseguer-penalver","tag-juan-antonio-madrid-perez","tag-liliana-jaso-friedmann","tag-maria-del-pilar-garcia-penarrubia","tag-pilar-lopez-fierro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16897"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16897\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}