{"id":16906,"date":"2018-03-09T09:04:44","date_gmt":"2018-03-09T09:04:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-genota%c2%adpico-de-tumores-del-sistema-nervioso-central\/"},"modified":"2018-03-09T09:04:44","modified_gmt":"2018-03-09T09:04:44","slug":"estudio-genota%c2%adpico-de-tumores-del-sistema-nervioso-central","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-genota%c2%adpico-de-tumores-del-sistema-nervioso-central\/","title":{"rendered":"Estudio genot\u00edpico de tumores del sistema nervioso central"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Belen Rodr\u00edguez S\u00e1nchez <\/strong><\/h2>\n<p>En la iniciaci\u00f3n y desarrollo de un turmo participan por igual factores ambientales y ciertas caracter\u00edsticas gen\u00e9ticas que permiten a la c\u00e9lula contrarrestar los efectos producidos por los primeros.  la fosfoprote\u00edna codificada por el gen supresor de tumores tp53 se expresa en respuesta al da\u00f1o producido en el dna, activando genes reparadores del dna o inductores de la apoptosis.  por otro lado, ciertos compuestos lipof\u00edlicos presentes en el medio ambiente o producidos durante el metabolismo celular, son capaces de unirse al adn y producir cambios en su estructura que podr\u00edan llevar a la aparici\u00f3n del fenotipo tumoral. El h\u00edgado, principal \u00f3rgano encargado de la eliminaci\u00f3n de estos compuestos, posee un conjunto de enzimas que llevan a cabo reacciones de reducci\u00f3n, oxidaci\u00f3n, transferencia de grupos azufre, glutation, etc, con el fin de convertir estos compuestos en otros m\u00e1s f\u00e1ciles de eliminar.  en este trabajo hemos analizado la presencia de mutaciones en las regiones conservadas evolutivamente del gen tp53 en 119 tumores del sistema nervioso central (snc), as\u00ed como la incidencia de polimorfismos en los intrones, 1,3,6 y 7 y en el ex\u00f3n 4 de dicho gen, asociados con una mayor predisposici\u00f3n a padecer otros tipos de c\u00e1ncer. Tambi\u00e9n hemos estudiado la incidencia de los polimorfismos presentes en cuatro enzimas metabolizadoras de compuestos cancer\u00edgenos (cyp2d6, gstm1, gstp1 y gstt1).  los resultados obtenidos indican que las mutaciones en el gen tp53 son poco frencuentes y, por tanto, desempe\u00f1an un papel secundario en el desarrollo de estos tumores. Adem\u00e1s el alelo pro72 de este gen est\u00e1 m\u00e1s representado en individuos sanos, lo que parece indicar que este alelo confiere cierto efecto protector frente al desarrollo de estos tumores. Por \u00faltimo, portar simult\u00e1neamente el gen gstt1 y el alelo a1 (\u00abbuen metablizador\u00bb) del gen cyp2d6 se asocia con una mayor predisposicion a padecer tumores del snc.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio genot\u00edpico de tumores del sistema nervioso central<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio genot\u00edpico de tumores del sistema nervioso central <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Belen Rodr\u00edguez S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rogelio Gonzalez Sarmiento<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jes\u00fas Cruz hern\u00e1ndez <\/li>\n<li> G\u00f3mez-moreta moreta Juan  Antonio (vocal)<\/li>\n<li>Manuel Jos\u00e9 Gayoso rodriguez (vocal)<\/li>\n<li>Carlos Rodr\u00edguez arias (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Belen Rodr\u00edguez S\u00e1nchez En la iniciaci\u00f3n y desarrollo de un turmo participan por igual factores ambientales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,35,9,962,11771,9386],"tags":[53176,53175,9551,53174,9985,26315],"class_list":["post-16906","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-genetica","category-genetica-clinica","category-salamanca","tag-carlos-rodriguez-arias","tag-gomez-moreta-moreta-juan-antonio","tag-juan-jesus-cruz-hernandez","tag-m-belen-rodriguez-sanchez","tag-manuel-jose-gayoso-rodriguez","tag-rogelio-gonzalez-sarmiento"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16906","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16906"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16906\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16906"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16906"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16906"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}