{"id":16916,"date":"2018-03-09T09:04:45","date_gmt":"2018-03-09T09:04:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-la-expresion-intrata%c2%admica-de-anta%c2%adgenos-involucrados-en-enfermedades-neurologicas-autoinmunitarias\/"},"modified":"2018-03-09T09:04:45","modified_gmt":"2018-03-09T09:04:45","slug":"caracterizacion-de-la-expresion-intrata%c2%admica-de-anta%c2%adgenos-involucrados-en-enfermedades-neurologicas-autoinmunitarias","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-de-la-expresion-intrata%c2%admica-de-anta%c2%adgenos-involucrados-en-enfermedades-neurologicas-autoinmunitarias\/","title":{"rendered":"Caracterizaci\u00f3n de la expresi\u00f3n intrat\u00edmica de ant\u00edgenos involucrados en enfermedades neurol\u00f3gicas autoinmunitarias"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Roxana Bruno <\/strong><\/h2>\n<p>El objetivo de este trabajo fue aclarar que autoant\u00edgenos est\u00e1n expresados en el timo humano, en que compartimentos y su relaci\u00f3n con la edad. Analizamos la expresi\u00f3n de los ant\u00edgenos involucrados en enfermedades neurol\u00f3gicas en tejidos control y en un panel de timos humanos, utilizando rt-pcr semi-cuantitativa, southern-blot y pcr radioactiva.  la titulaci\u00f3n de los cebadores y la normalizaci\u00f3n permitieron calcular el n\u00famero de copias por muestra. Tambi\u00e9n examinamos las princiaples fracciones celulares t\u00edmicas y microdisecciones de cortezas y m\u00e9dulas, obtenidas por captura l\u00e1ser. La disecci\u00f3n por captura l\u00e1ser contribuy\u00f3 a elucidar la localizaci\u00f3n de las c\u00e9lulas que expresan los autoant\u00edgenos. La expresi\u00f3n del autoant\u00edgeno de la miastenia grave (mg), el receptor nicot\u00ednico de acetilcolina (achr), present\u00f3 tres patrones diferentes designados como constitutivo (subunidades beta y *), variable (subunidades alfa y *) y dependiente del desarrollo (subunidad gamma).  el estudio de nueve gl\u00e1ndulas con miastenia grave y un timona fue consistente con los patrones de expresi\u00f3n propuestos.  los experimentos para elucidar el compartimento t\u00edmico donde se expresa el achr, revelaron mayor nivel de expresi\u00f3n en la m\u00e9dula, donde se agrupan las c\u00e9lulas mioides.  los ant\u00edgenos plp, alfab-cristalina y s100beta involucrados en esclerosis m\u00faltiple (ms) est\u00e1n expresados en el timo y tambi\u00e9n en otros tejdios perif\u00e9ricos no inmunitarios.  el nivel de expresi\u00f3n fue m\u00e1s alto en la fracci\u00f3n celular enriquecida en las c\u00e9lulas epiteliales y en el comportamiento medular de las microdisecciones.  por el contrario, no observamos la expresi\u00f3n de mog fuera del sistema nervioso central, siendo mog el ejemplo cl\u00e1sico de ant\u00edgeno secuestrado y confirmando su participaci\u00f3n en las enfermedades autoinmunitarias desmielinizantes.  el an\u00e1lisis de la expresi\u00f3n del ant\u00edgeno prost\u00e1tico espec\u00edfico (psa) y del ant\u00edgeno espec\u00edfico<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de la expresi\u00f3n intrat\u00edmica de ant\u00edgenos involucrados en enfermedades neurol\u00f3gicas autoinmunitarias<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de la expresi\u00f3n intrat\u00edmica de ant\u00edgenos involucrados en enfermedades neurol\u00f3gicas autoinmunitarias <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Roxana Bruno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Pujol Borrell<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: dolores Jaraquemada p\u00e9rez de guzm\u00e1n <\/li>\n<li>Miguel Lopez botet arbona (vocal)<\/li>\n<li>Antonio Iglesias-tejada (vocal)<\/li>\n<li>francesc Graus  ribas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Roxana Bruno El objetivo de este trabajo fue aclarar que autoant\u00edgenos est\u00e1n expresados en el timo humano, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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