{"id":16934,"date":"2018-03-09T09:04:46","date_gmt":"2018-03-09T09:04:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/tipificacion-molecular-perfil-de-sensibilidad-a-antimicrobianos-y-caracterizacion-de-los-qrdr-de-las-topoisomerasas-ii-y-iv-en-stenotrophomonas-maltophilia\/"},"modified":"2018-03-09T09:04:46","modified_gmt":"2018-03-09T09:04:46","slug":"tipificacion-molecular-perfil-de-sensibilidad-a-antimicrobianos-y-caracterizacion-de-los-qrdr-de-las-topoisomerasas-ii-y-iv-en-stenotrophomonas-maltophilia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/tipificacion-molecular-perfil-de-sensibilidad-a-antimicrobianos-y-caracterizacion-de-los-qrdr-de-las-topoisomerasas-ii-y-iv-en-stenotrophomonas-maltophilia\/","title":{"rendered":"Tipificaci\u00f3n molecular, perfil de sensibilidad a antimicrobianos y caracterizaci\u00f3n de los qrdr de las topoisomerasas ii y iv en stenotrophomonas maltophilia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sylvia Valdezate Ramos <\/strong><\/h2>\n<p>El estudio de la epidemiolog\u00eda de la infecci\u00f3n\/colonizaci\u00f3n de stenotrophomonas maltophilia en pacientes con fibrosis qu\u00edstica (fq) indic\u00f3 que durante el per\u00edodo 91-98 la incidencia y preValencia anual fluctu\u00f3 entre el 2,9-8,8% y el 3,3-15,9%, respectivamente. La tipificaci\u00f3n de los aislamientos mediante electroforesis en campo pulsado (pfge) mostraron valores de incidencia clonal anual que oscilaron el 3,3-16,3%, resaltando la ausencia de una tendencia clara al aumento de estos pacientes. En 24% de los pacientes en los que se aisl\u00f3 s.Maltophilia se evidenciaron dos situaciones: 14 pacientes (56%) presentaron un \u00fanico cultivo positivo y 11 (44%) presentaron episodios repetidos, diferenci\u00e1ndose un patr\u00f3n de persistencia de uno o dos clones en 5 y 1 paciente, respectivamente, y un patr\u00f3n de variabilidad de diferentes clones en 5 pacientes.  la adquisici\u00f3n nosocomial de s.Maltophilia en los pacientes hospitalizados no-fq se realiz\u00f3 de formas independiente, observ\u00e1ndose una gran heterogeneidad en los perfiles gen\u00f3micos, sin encontrarse agrupaciones clonales en funci\u00f3n del tipo de muestra, tipo de infecci\u00f3n o el servicio cl\u00ednico de procedencia del paciente.  los antimicrobianos con un menor porcentaje de resistencia en los aislamientos de los dos grupos de pacientes (fq y no-fq) fueron la minociclina (0%), y doxiciclina (0-1%), las nuevas quinolonas (&lt;11-4%), el moxalactam (17-2%) y el cotrimoxazol (25,4-27%). Las combinaciones ticarcilina-clavul\u00e1nico y aztreonam-clavul\u00e1nico restauraron la actividad de ticarcilina y el aztreonam por el \u00e1cido clavul\u00e1nico en un 40,2-27,3% y 32,2-26,2%.  en la caracterizaci\u00f3n de las regiones determinantes de las resistencias a quinolonas \u00abqrdr\u00bb de las topoisomerasas ii y iv en 32 cepas cl\u00ednicas con diferentes valores de cmi a ciprofloxacina (0,1-64 ug\/ml), no se detectaron cambios en las posiciones habitualmente relacionadas con la resistencia a quinolonas en otros microorganismos,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Tipificaci\u00f3n molecular, perfil de sensibilidad a antimicrobianos y caracterizaci\u00f3n de los qrdr de las topoisomerasas ii y iv en stenotrophomonas maltophilia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Tipificaci\u00f3n molecular, perfil de sensibilidad a antimicrobianos y caracterizaci\u00f3n de los qrdr de las topoisomerasas ii y iv en stenotrophomonas maltophilia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sylvia Valdezate Ramos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Cant\u00f3n Moreno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: c\u00e9sar Nombela cano <\/li>\n<li> S\u00e1ez nieto Juan  Antonio (vocal)<\/li>\n<li>Fernando Baquero mochales (vocal)<\/li>\n<li>isabel Morosini Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sylvia Valdezate Ramos El estudio de la epidemiolog\u00eda de la infecci\u00f3n\/colonizaci\u00f3n de stenotrophomonas maltophilia en pacientes con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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