{"id":16950,"date":"2018-03-09T09:04:47","date_gmt":"2018-03-09T09:04:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/repercusiones-de-la-administracion-de-ipamorelin-nuevo-secretagogo-de-gh-en-ratas-respuesta-in-vitro-de-las-celulas-somatotropas\/"},"modified":"2018-03-09T09:04:47","modified_gmt":"2018-03-09T09:04:47","slug":"repercusiones-de-la-administracion-de-ipamorelin-nuevo-secretagogo-de-gh-en-ratas-respuesta-in-vitro-de-las-celulas-somatotropas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/repercusiones-de-la-administracion-de-ipamorelin-nuevo-secretagogo-de-gh-en-ratas-respuesta-in-vitro-de-las-celulas-somatotropas\/","title":{"rendered":"Repercusiones de la administraci\u00f3n de ipamorelin (nuevo secretagogo de gh) en ratas: respuesta \u00abin vitro\u00bb de las c\u00e9lulas somatotropas"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Torre Aguilar M. Jos\u00e9 De La <\/strong><\/h2>\n<p>La gh es secretada por las c\u00e9lulas somatotropas de la adenohip\u00f3fisis. su secreci\u00f3n est\u00e1 regulada por ghrh y srih. Un tercer sistema, el de ghs parece que tambi\u00e9n esta implicado en su regulaci\u00f3n. En esta tesis hemos estudiado las repercusiones de la administraci\u00f3n cr\u00f3nica (21 d\u00edas) del ghs ipamorelin sobre el peso de los animales y la ultraestructura de las c\u00e9lulas somatotropas de rata y la liberaci\u00f3n global e individual de gh in vitro. Tambi\u00e9n hemos estudiado la proporci\u00f3n de c\u00e9lulas somatotropas y sus subtipos en cada uno de los distintos grupos experimentales. Hemos utilizado ratas wistar hembra de 60 d\u00edas de vida y se han dividido en: un grupo ipamorelin (al que se administra 100 mg\/kg\/d\u00eda sc), un grupo ghrh (al que se administra 10mg\/kg\/d\u00eda sc) y un grupo salino que recibe el mismo volumen de suero salino. Al finalizar el tratamiento se realizan estudios morfol\u00f3gicos y funcionales, in vitro.  in vivo, hemos pesado diariamente a los animales y estudiado las c\u00e9lulas somatotropas mediante t\u00e9cnicas de microscop\u00eda \u00f3ptica, y electr\u00f3nica y m\u00e9todos estereol\u00f3gicos. Los resultados obtenidos indican que la administraci\u00f3n de ipamorelin durante 21 d\u00edas produce un incremento de peso y un aumento de la densidad de volumen de los gr\u00e1nulos de secreci\u00f3n.  asimismo, hemos cultivado las c\u00e9lulas hipofisarias de sendos grupos de animales tras realizar la dispersi\u00f3n de las adenohip\u00f3fisis en monocapa y sobre membranas de immobilon para estudiar los apsectos funcionales (de secreci\u00f3n global e individual de gh) y morfol\u00f3gicos (inmunoti\u00f1endo las c\u00e9lulas somatotropas al finalizar el cultivo) de estas c\u00e9lulas. En el grupo ipamorelin observamos que los est\u00edmulos con ipamorelin, ghrp6, ghrh, srih y srih+ipamorelin aumentan el porcentaje de c\u00e9lulas somatotropas, sin modificar la proporci\u00f3n de c\u00e9lulas claras y oscuras. Los est\u00edmulos positivos incrementan la liberaci\u00f3n de gh, mientras que srih es capaz de inhibir la liberaci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Repercusiones de la administraci\u00f3n de ipamorelin (nuevo secretagogo de gh) en ratas: respuesta \u00abin vitro\u00bb de las c\u00e9lulas somatotropas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Repercusiones de la administraci\u00f3n de ipamorelin (nuevo secretagogo de gh) en ratas: respuesta \u00abin vitro\u00bb de las c\u00e9lulas somatotropas <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Torre Aguilar M. Jos\u00e9 De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Ca\u00f1ete Estrada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan a (secretario) Guzman caba\u00f1as <\/li>\n<li>salvador Per\u00e1n  mesa (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Torre Aguilar M. Jos\u00e9 De La La gh es secretada por las c\u00e9lulas somatotropas de la adenohip\u00f3fisis. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,9,973,9399,851,139,2008],"tags":[53288,2403,8001,53287],"class_list":["post-16950","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-ciencias-medicas","category-cordoba","category-cultivo-celular","category-endocrinologia","category-medicina-interna","category-morfologia-celular","tag-juan-a-secretario-guzman-cabanas","tag-ramon-canete-estrada","tag-salvador-peran-mesa","tag-torre-aguilar-m-jose-de-la"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16950","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16950"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16950\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16950"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16950"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}