{"id":16971,"date":"2018-03-09T09:04:49","date_gmt":"2018-03-09T09:04:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/significado-cla%c2%adnico-de-la-enfermedad-ma%c2%adnima-residual-en-el-mieloma-multiple\/"},"modified":"2018-03-09T09:04:49","modified_gmt":"2018-03-09T09:04:49","slug":"significado-cla%c2%adnico-de-la-enfermedad-ma%c2%adnima-residual-en-el-mieloma-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/significado-cla%c2%adnico-de-la-enfermedad-ma%c2%adnima-residual-en-el-mieloma-multiple\/","title":{"rendered":"Significado cl\u00ednico de la enfermedad m\u00ednima residual en el mieloma m\u00faltiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joaquin Martinez Lopez <\/strong><\/h2>\n<p>Objetivo  analizar el significado cl\u00ednico de la respuesta al tratamiento en el mieloma m\u00faltiple mediante m\u00e9todos bioqu\u00edmicos y moleculares.  material y m\u00e9todos  estudio de electroforesis frente a inmunofijaci\u00f3n en la evaluaci\u00f3n de la respuesta. Se ha estudiado la respuesta al trasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos en 324 pacientes. Se ha evaluado la respuesta mediante electroforesis de prote\u00ednas e inmunofijaci\u00f3n de inmunoglobulinas en el momento de m\u00e1xima respuesta al tratamiento. Estudio del significado pron\u00f3stico de la enfermedad m\u00ednima residual medida mediante pcr. Se han estudiado mediante pcr de las regioens cdr1, 2 y 3 del gen igh 46 enfermos al diagn\u00f3stico y se ha realizado seguimiento en 16 sometidos a trasplante aut\u00f3logo. optimizaci\u00f3n de un m\u00e9todo de aleloespec\u00edfico de pcr en tiempo real empleando como sonda mol\u00e9culas beacon.  resultados  estudio de electroforesis frente a inmunofijaci\u00f3n en la evaluaci\u00f3n de la respuesta. Establecimos 3 grupos de respuesta al tratamiento:  1,- rc 1 remisi\u00f3n completa definida mediante inmunofijaci\u00f3n.  2,- rc 2, pr1 y pr2 (cualquier otro tipo de respuesta).  3,- no respuesta.  esta clasificaci\u00f3n alcanza una elevada significaci\u00f3n tanto para la sg (p=0,00000) como para la sle (p=0,00000). Los valores del grupo resultante tras unificar rc2, rp1 y pr2 son: sg, 40% a los 5 a\u00f1os con una mediana de 47 meses y sle del 19% a los 5 a\u00f1os con una mediana de 29 meses: en contraposici\u00f3n a los valores ya referidos del grupo de rc1 con porcentajes para sg y s le a los 5 a\u00f1os de 71% y 35%.  estudio del significaci\u00f3n pron\u00f3stico de la enfermedad m\u00ednima residual medida mediante pcr. De los 16 enfermos que se realiz\u00f3 seguimiento mediante pcr cualitativa del gen igh, en ning\u00fan caso se alcanz\u00f3 respuesta molecular. la pcr en tiempo real del igh empleando sondas beacon tiene una reproductibilidad intraensayo de 2,7% y una reproductivilidad interesnayo de 6,15%.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Significado cl\u00ednico de la enfermedad m\u00ednima residual en el mieloma m\u00faltiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Significado cl\u00ednico de la enfermedad m\u00ednima residual en el mieloma m\u00faltiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joaquin Martinez Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Lahuerta Palacios Juan  Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Lanzos gonz\u00e1lez <\/li>\n<li>marcos Gonzalez diaz (vocal)<\/li>\n<li>joan Blade crexenti (vocal)<\/li>\n<li> Cabrera mar\u00edn Jos\u00e9 Rafael (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joaquin Martinez Lopez Objetivo analizar el significado cl\u00ednico de la respuesta al tratamiento en el mieloma m\u00faltiple [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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