{"id":16991,"date":"2018-03-09T09:04:51","date_gmt":"2018-03-09T09:04:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-hormona-de-crecimiento-gh-y-la-dieta-hiperproteica-como-factores-protectores-frente-a-la-quimioterapia-con-5-fluorouracilo-en-un-modelo-de-adenocarcinoma-de-colon-en-la-rata\/"},"modified":"2018-03-09T09:04:51","modified_gmt":"2018-03-09T09:04:51","slug":"efecto-de-la-hormona-de-crecimiento-gh-y-la-dieta-hiperproteica-como-factores-protectores-frente-a-la-quimioterapia-con-5-fluorouracilo-en-un-modelo-de-adenocarcinoma-de-colon-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-hormona-de-crecimiento-gh-y-la-dieta-hiperproteica-como-factores-protectores-frente-a-la-quimioterapia-con-5-fluorouracilo-en-un-modelo-de-adenocarcinoma-de-colon-en-la-rata\/","title":{"rendered":"Efecto de la hormona de crecimiento (gh) y la dieta hiperproteica como factores protectores frente  a la quimioterapia con 5-fluorouracilo, en un modelo de adenocarcinoma de colon en la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Clavijo \u00e1lvarez Julio Alfonso <\/strong><\/h2>\n<p>La hormona de crecimiento ha sio propuesta como un m\u00e9todo efectivo para la prevenci\u00f3n del tratamiento con quimio o radioterapia en el intestino. el objetivo de este estudio fue determinar si la administraci\u00f3n ex\u00f3gena de hormona de crecimiento asociada a dieta hiperproteica modifica el efecto delet\u00e9ro del 5-fluorouracilo (5-fu) en el intestino y en el adenocarcinoma de colon en la rata.  m\u00e9todos  se empleo la l\u00ednea tumoral dhd-k12-trb, que fue estudiada en cultivos celulares y tambi\u00e9n fue implantada en ratas sing\u00e9nicas (bd-ix). Tanto los cultivos celulares como los animales fueron tratados con hormona de crecimiento y 5-fu. En los cultivos celulares se evalu\u00f3 el crecimiento de las c\u00e9lulas, la proliferaci\u00f3n y apoptosis. En los animales se evalu\u00f3 la masa tumoral (volumen, peso tumoral, anatom\u00eda patol\u00f3gica, proliferaci\u00f3n y apoptosis) y el \u00edleon (morfometr\u00eda de la vellosidad y la cripta, proliferaci\u00f3n y apoptosis).  resultados  la gh protegi\u00f3 al intenso contra el efecto del 5-fu, mediante un aumento de la proliferaci\u00f3n y una disminuci\u00f3n de la apoptosis de la cripta intestinal. en el tumor se observ\u00f3 una inhibici\u00f3n de la proliferaci\u00f3n del tumor con la administraci\u00f3n de 5-fu. Este efecto no fue modificado por la administraci\u00f3n de gh.  conclusi\u00f3n  la gh protege al intestino del efecto delet\u00e9reo del 5-fu sin alterar el efecto de este quimioter\u00e1pico sobre el tumor.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la hormona de crecimiento (gh) y la dieta hiperproteica como factores protectores frente  a la quimioterapia con 5-fluorouracilo, en un modelo de adenocarcinoma de colon en la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la hormona de crecimiento (gh) y la dieta hiperproteica como factores protectores frente  a la quimioterapia con 5-fluorouracilo, en un modelo de adenocarcinoma de colon en la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Clavijo \u00e1lvarez Julio Alfonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>De Miguel Enrique<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Castillo-olivares ramos Jos\u00e9 Luis <\/li>\n<li>eduardo Arilla ferreiro (vocal)<\/li>\n<li>Jaime Arias p\u00e9rez (vocal)<\/li>\n<li> Pajares Garc\u00eda Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Clavijo \u00e1lvarez Julio Alfonso La hormona de crecimiento ha sio propuesta como un m\u00e9todo efectivo para la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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