{"id":17051,"date":"2018-03-09T09:04:57","date_gmt":"2018-03-09T09:04:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/a-novel-solenoid-fold-in-the-cell-wall-anchoring-domain-of-the-pneumococcal-virulence-factor-lyta-implications-for-rational-drug-design-against-pneumococcus\/"},"modified":"2018-03-09T09:04:57","modified_gmt":"2018-03-09T09:04:57","slug":"a-novel-solenoid-fold-in-the-cell-wall-anchoring-domain-of-the-pneumococcal-virulence-factor-lyta-implications-for-rational-drug-design-against-pneumococcus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/a-novel-solenoid-fold-in-the-cell-wall-anchoring-domain-of-the-pneumococcal-virulence-factor-lyta-implications-for-rational-drug-design-against-pneumococcus\/","title":{"rendered":"A novel solenoid fold in the cell wall anchoring domain of the pneumococcal virulence factor lyta. implications for rational drug design against pneumococcus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Fern\u00e1ndez Tornero <\/strong><\/h2>\n<p>El fuerte incremento en las tasas de resistencia a los distintos antibi\u00f3ticos y la baja eficiencia cl\u00ednica de la vacuna disponible impiden el control del streptococcus pneumoniae, el agente bacteriano con mayor \u00edndice de mortalidad en el mundo. La necesidad de nuevos f\u00e1rmacos ha dirigido a los cient\u00edficos hacia el estudio de factores de virulencia bacteriana tales como las prote\u00ednas de uni\u00f3n a colina, una familia de quince polip\u00e9ptidos localizados en la superficie celular de este pat\u00f3geno. La primera estructura de un dominio de uni\u00f3n a colina, el de la principal autolisina de neumococo, descubre un nuevo plegamiento que consiste exclusivamente en una serie de horquillas beta que se empaquetan para formar un solenoide o superh\u00e9lice a izquierdas. Esta estructura \u00fanica se estabiliza a trav\u00e9s de una serie de mol\u00e9culas de colina, localizadas en peque\u00f1as cavidades hidrof\u00f3bicas de la superficie proteica que aparecen en la interfaz de horquillas beta consecutivas. Adem\u00e1s, la estructura resuelta presenta una serie de surcos en la superficie, que podr\u00edan estar implicados en la interacci\u00f3n con el componente glic\u00eddico de los \u00e1cidos teicoico y lipoteicoico a los cuales se encuentran ancladas las prote\u00ednas de uni\u00f3n a colina. Puesto que dicho anclaje es esencial para la virulencia bacteriana, su liberalizaci\u00f3n de la pared celular est\u00e1 considerada como una v\u00eda terap\u00e9utica alternativa contra este pat\u00f3geno. El conocimiento de la estructura del dominio de anclaje de una de estas prote\u00ednas nos ha permitido el hallazgo de un posible nuevo f\u00e1rmaco que podr\u00eda, no s\u00f3lo ser efectivo contra el neumococo sino tambi\u00e9n contra otras bacterias gram-positivas que contienen prote\u00ednas con este dominio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>A novel solenoid fold in the cell wall anchoring domain of the pneumococcal virulence factor lyta. implications for rational drug design against pneumococcus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 A novel solenoid fold in the cell wall anchoring domain of the pneumococcal virulence factor lyta. implications for rational drug design against pneumococcus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Fern\u00e1ndez Tornero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Guillermo Gimenez Gallego<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: margarita Salas falgueras <\/li>\n<li>xavier Gomis-r\u00ed\u00bcth f. (vocal)<\/li>\n<li>robert Huber (vocal)<\/li>\n<li>ernesto Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Fern\u00e1ndez Tornero El fuerte incremento en las tasas de resistencia a los distintos antibi\u00f3ticos y la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2193,36483,36606,160,115,35,278,17],"tags":[53570,53573,15592,15196,53572,53571],"class_list":["post-17051","post","type-post","status-publish","format-standard","hentry","category-antibioticos","category-biologia-molecular","category-biologia-molecular-de-microorganismos","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-microbiologia","category-quimica","tag-carlos-fernandez-tornero","tag-ernesto-garcia","tag-guillermo-gimenez-gallego","tag-margarita-salas-falgueras","tag-robert-huber","tag-xavier-gomis-rith-f"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17051"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17051\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}