{"id":17130,"date":"2018-03-09T09:05:03","date_gmt":"2018-03-09T09:05:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-de-vectores-virales-adeno-asociados-para-transferencia-genica-al-musculo-y-su-aplicacion-a-un-modelo-de-cirrosis-experimental\/"},"modified":"2018-03-09T09:05:03","modified_gmt":"2018-03-09T09:05:03","slug":"desarrollo-de-vectores-virales-adeno-asociados-para-transferencia-genica-al-musculo-y-su-aplicacion-a-un-modelo-de-cirrosis-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/desarrollo-de-vectores-virales-adeno-asociados-para-transferencia-genica-al-musculo-y-su-aplicacion-a-un-modelo-de-cirrosis-experimental\/","title":{"rendered":"Desarrollo de vectores virales adeno-asociados para transferencia g\u00e9nica al musculo y su aplicaci\u00f3n a un modelo de cirrosis experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Zaratiegui Biurrun Miguel Angel <\/strong><\/h2>\n<p>La transferencia genica al m\u00fasculo es una de las estrategias de terapia genica de mayor aplicabilidad hoy en d\u00eda. El vector m\u00e1s prometedor para esta aplicaci\u00f3n son los virus recombinantes adeno-asociados. Sin embargo su uso no esta exento de dificultades: la producci\u00f3n es dif\u00edcil y el producto final est\u00e1 frecuentemente contaminado con adenovirus. Hemos desarrollado un sistema de complementaci\u00f3n que hace uso del sistema cre-loxp para volver al adenovirus inempaquetable reduciendo asi su titulo en la preparaci\u00f3n de raav. Hemos comparado la eficiencia y la duraci\u00f3n de la expresi\u00f3n de los raav producidos con este protocolo con las de otros dos vectores de transferencia genica al m\u00fasculo: el dna-pvp y los h\u00edbridos hvj-liposomas. los resultados demuestran que la eficiencia de los raav aumenta con el tiempo llegando al m\u00e1ximo entre 8 y 16 semanas tras la inyecci\u00f3n en m\u00fasculos, tibialis anterior del rat\u00f3n, mientras que el dna-pvp tiene un m\u00e1ximo de expresi\u00f3n la primera semana tras la inyecci\u00f3n. Los hvj-liposomas mostraron eficiencias inferiores durante todo el estudio. Para comprobar la eficacia terapeutica de estos vectores in vivo utilizamos el modelo de cirrosis por inhalaci\u00f3n de ccl4 e inyecci\u00f3n de un aav que codifica la igf1 de rata. la inyecci\u00f3n intramuscular de aavigf1 no produjo efecto terap\u00e9utico en las ratas cirroticas? Quedando su efecto recluido en el tejido inyectado y provocando hipertrofia muscular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo de vectores virales adeno-asociados para transferencia g\u00e9nica al musculo y su aplicaci\u00f3n a un modelo de cirrosis experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo de vectores virales adeno-asociados para transferencia g\u00e9nica al musculo y su aplicaci\u00f3n a un modelo de cirrosis experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Zaratiegui Biurrun Miguel Angel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Novo Villaverde Francisco Javier<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>Miguel Chillon rodriguez (vocal)<\/li>\n<li>ignacio Lopez go\u00f1i (vocal)<\/li>\n<li>Miguel Pocovi mieras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Zaratiegui Biurrun Miguel Angel La transferencia genica al m\u00fasculo es una de las estrategias de terapia genica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,962,4578,17749],"tags":[53779,15059,53778,10660,52607,53777],"class_list":["post-17130","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-genetica","category-ingenieria-genetica","category-navarra","tag-ignacio-lopez-goni","tag-jesus-m-prieto-valtuena","tag-miguel-chillon-rodriguez","tag-miguel-pocovi-mieras","tag-novo-villaverde-francisco-javier","tag-zaratiegui-biurrun-miguel-angel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17130"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17130\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17130"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}