{"id":17140,"date":"2018-03-09T09:05:04","date_gmt":"2018-03-09T09:05:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/incidencia-de-los-contaminantes-ambientales-genotoxicos-en-celulas-de-trucha-arcoiris-oncohynchus-mykiss\/"},"modified":"2018-03-09T09:05:04","modified_gmt":"2018-03-09T09:05:04","slug":"incidencia-de-los-contaminantes-ambientales-genotoxicos-en-celulas-de-trucha-arcoiris-oncohynchus-mykiss","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/incidencia-de-los-contaminantes-ambientales-genotoxicos-en-celulas-de-trucha-arcoiris-oncohynchus-mykiss\/","title":{"rendered":"Incidencia de los contaminantes ambientales genotoxicos en celulas de trucha arcoiris (oncohynchus mykiss)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Concepci\u00f3n Becerril Moral <\/strong><\/h2>\n<p>Los compuestos xenobi\u00f3ticos presentes en el medio acu\u00e1tico pueden alterar la estructura y funci\u00f3n del adn de los organismos expuestos. En funci\u00f3n del tipo de contaminante, concentraci\u00f3n y permanencia en el medio, sus efectos puden manifestarse provocando mutaciones o da\u00f1os citogen\u00e9ticos a nivel de individuo, y\/o pueden llegar a alterar la diversidad gen\u00e9tica de las poblaciones expuestas tras periodos m\u00e1s o menos largos de tiempo. la valoraci\u00f3n a priori de tales alteraciones constituye uno de los retos actuales de la ecotoxicolog\u00eda e implica el desarrollo de metodolog\u00edas capaces de predecir los efectos genot\u00f3xicos de dichos contaminantes.  este trabajo ha ido dirigido en este sentido, desarrollando un modelo sencillo y representativo del medio acu\u00e1tico capaz de detectar da\u00f1os inespec\u00edficos en el adn. Para ello se ha utilizado conjuntamente la l\u00ednea celular rtg-2 procedente de trucha arcoiris, y la t\u00e9cnica de rapd (amplificaci\u00f3n al azar de polimorfismos de adn) capaz de detectar de forma sencilla cambios en la mol\u00e9cula de adn. El desarrollo de esta metodolog\u00eda se ha llevado a cabo siguiendo los siguientes pasos:  1,- se ha desarrollado un protocolo de la t\u00e9cnica, ajustando cada uno de los par\u00e1metros que intervienen en ella.  2,- se ha obtenido un patr\u00f3n de bandas espec\u00edfico y altamente reproducible del sistema biol\u00f3gico utilizado que ha mostrado, tras exposiciones agudas y cr\u00f3nicas a diferentes genot\u00f3xicos (mitomicina c y benzo(a)pireno), una gran capacidad y sensibilidad en la detecci\u00f3n de alteraciones en el adn de las c\u00e9lulas expuestas.  3,- se ha comprobado la posibilidad de extrapolar los resultados obtenidos en este sistema \u00abin vitro\u00bb a \u00abin vivo\u00bb, ya que ambos sistemas presentan una alta similaridad gen\u00e9tica y los efectos observados \u00abin vitro\u00bb tras exponer a b(a)p individuos de trucha arcoiris, son similares a los obtenidos \u00abin vitro\u00bb, a pesar de que la presencia de bandas polim\u00f3rficas dificulta su a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Incidencia de los contaminantes ambientales genotoxicos en celulas de trucha arcoiris (oncohynchus mykiss)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Incidencia de los contaminantes ambientales genotoxicos en celulas de trucha arcoiris (oncohynchus mykiss) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Concepci\u00f3n Becerril Moral <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Argelia Casta\u00f1o Calvo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Casado gonz\u00e1lez <\/li>\n<li>f\u00e9lix Sanz barrera (vocal)<\/li>\n<li>Mar\u00eda  pilar Lopez luna (vocal)<\/li>\n<li>guillermo Repetto kuhn (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Concepci\u00f3n Becerril Moral Los compuestos xenobi\u00f3ticos presentes en el medio acu\u00e1tico pueden alterar la estructura y funci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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