{"id":17144,"date":"2018-03-09T09:05:05","date_gmt":"2018-03-09T09:05:05","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/resolucion-enzimatica-de-aminoalcoholes-preparacion-de-compuestos-de-interes-biologico\/"},"modified":"2018-03-09T09:05:05","modified_gmt":"2018-03-09T09:05:05","slug":"resolucion-enzimatica-de-aminoalcoholes-preparacion-de-compuestos-de-interes-biologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/resolucion-enzimatica-de-aminoalcoholes-preparacion-de-compuestos-de-interes-biologico\/","title":{"rendered":"Resoluci\u00f3n enzim\u00e1tica de aminoalcoholes: preparaci\u00f3n de compuestos de interes biol\u00f3gico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Amparo Luna Costales <\/strong><\/h2>\n<p>Las lipasas son catalizadores que han mostrado una alta eficacia y selectividad en reacciones de amin\u00f3lisis y transesterificaci\u00f3n. Mediante estos procesos se obtienen alcoholes, esteres, aminas y amidas \u00f3pticamente activas, compuestos de gran inter\u00e9s en la s\u00edntesis de productos con actividad farmacol\u00f3gica.  en esta memoria se han utilizado de amin\u00f3lisis y transesterificaci\u00f3n catalizadas por lipasas para la resoluci\u00f3n de 1,2-aminoalcoholes y 1,2-diaminas, estructuradas presentes en compuestos con actividad biol\u00f3gica.  cap\u00edtulo 1  se utiliza la reacci\u00f3n de transesterificaci\u00f3n enzim\u00e1tica catalizada por la lipasa de pseudomonas cepacia (psl) para la resoluci\u00f3n del derivado n-benciloxicarbonilo del (?)-Cis-2-aminociclopentanol y la lipasa de candida antarcitca (calb) para la resoluci\u00f3n del n-benciloxicarbonilo del (?)-Cis-2-aminociclohexanol. este trabajo se encuentra recogido en la siguiente publicaci\u00f3n:  a. Luna, c. Astorga, f. F\u00ed\u00bcl\u00ed\u00b6p, v. Gotor, \u00abezymatic resolution of (?)-Cis-2-aminocyclopentanol and (?)-Cis-2-aminocyclohexanol\u00bb, tetrahedron: asymmetry, 1998, 9, 4483.  cap\u00edtulo 2  en este cap\u00edtulo, la psl cataliza de forma eficaz la resoluci\u00f3n de los correspondientes derivados n-benciloxicarbonilados (?)-Cis- y(?)-Trans-1-aminoindan-2-ol a trav\u00e9s de una reacci\u00f3n de o-acilaci\u00f3n. De forma similar, el (?)-Cis-n-cbz-2-aminoindan-1-ol tambi\u00e9n fue resuelto. El valor de enantioselectividad que se obtiene para el (?)-Trans-n-cbz-2-aminoindan-1-ol fue bajo debido a que este sustrato presenta dos conf\u00f3rmeros con requerimiento est\u00e9ricos contrarios. Este trabajo ha dado lugar a la siguiente publicaci\u00f3n:  a. Luna, a. Maestro, c. Astorga, v. Gotor, \u00abezymatic resolution of (?)-Cis-anda (?)-Trans-1-aminoindan-2-ol and (?)-Cis- y (?)-Trans-2-aminoindan-1-ol\u00bb, tetrahedron: asymmetry, 1999, 10, 1969.  cap\u00edtulo 3  en este cap\u00edtulo, se resuelve de forma exitosa el (?)-2-(1-adamantil)-2-aminoetanol. este aminoalcohol primar<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Resoluci\u00f3n enzim\u00e1tica de aminoalcoholes: preparaci\u00f3n de compuestos de interes biol\u00f3gico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Resoluci\u00f3n enzim\u00e1tica de aminoalcoholes: preparaci\u00f3n de compuestos de interes biol\u00f3gico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Amparo Luna Costales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Gotor Santamar\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marcial Moreno ma\u00f1as <\/li>\n<li>Jos\u00e9 Manuel Saa rodriguez (vocal)<\/li>\n<li>Miguel \u00e1ngel Yus astiz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Amparo Luna Costales Las lipasas son catalizadores que han mostrado una alta eficacia y selectividad en reacciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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