{"id":17174,"date":"2002-01-06T00:00:00","date_gmt":"2002-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-tratamiento-s-adenosilmetionina-sobre-la-fibrosos-hepatica-experimental-temprana-papel-de-oxido-na%c2%adtrico\/"},"modified":"2002-01-06T00:00:00","modified_gmt":"2002-01-06T00:00:00","slug":"efecto-del-tratamiento-s-adenosilmetionina-sobre-la-fibrosos-hepatica-experimental-temprana-papel-de-oxido-na%c2%adtrico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/efecto-del-tratamiento-s-adenosilmetionina-sobre-la-fibrosos-hepatica-experimental-temprana-papel-de-oxido-na%c2%adtrico\/","title":{"rendered":"Efecto del tratamiento s-adenosilmetionina sobre la fibrosos hep\u00e1tica experimental temprana. papel de \u00f3xido n\u00edtrico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Jose Mesonero Alvarez <\/strong><\/h2>\n<p>La mayor\u00eda de las enfermedades hep\u00e1ticas cr\u00f3nicas se caracterizan por el desarrollo de fibrosis con ac\u00famulo de componentes de la matriz extracelular. la cirrosis es el estado evolutivo final de este proceso.  estudios previos describen la relaci\u00f3n que existe entre cirrosis y trastornos del ciclo de la metilaci\u00f3n. La cirrosis, sea cual sea su etiolog\u00eda, deprime la actividad de la metionina adenosiltransferasa (mat) que es la enzima responsable de la s\u00edntesis de s-adenosilmetionina (same). A su vez, se ha demostrado que el \u00f3xido n\u00edtrico (no) est\u00e1 intimamente relacionado con la s\u00edntesis de same, ya que inhibe directamente la mat. El modelo experimental de fibrosis inducida por ligadura del conducto biliar com\u00fan (lcb) provoca adem\u00e1s de colestasis, un fen\u00f3meno fibr\u00f3tico ya patente a las dos semanas de la cirug\u00eda.  el objetivo principal de esta tesis es comprobar el papel de gsh y\/o no en los estadios precoces de la fibrosis hep\u00e1tica, dilucidar las v\u00edas por las que esto ocurre y estudiar posibles formas de actuaci\u00f3n estudiando el efecto de diferentes tratamientos farmacol\u00f3gicos que, actuando v\u00eda gsh\/no, permitan o no evitar o reducir la progresi\u00f3n de la fibrosis. Para ello utilizamos una sustancia que mejora los mecanismos antioxidantes: s-adenosilmetionina (same) y dos sustancias inhibidoras de la producci\u00f3n de no: ng- nitro-l-arginina-metil-\u00e9ster (l-name) y la aminoguanidina (ag).  las conclusiones del trabajo son las siguientes:  la lcb induce, ya a los 17 d\u00edas, hiperplasia ductular, fibrosis de predominio periportal, deterioro de la funci\u00f3n hep\u00e1tica y cambios hemodin\u00e1micos confirmando la fiabilidad del modelo experimental elegido.  existe expresi\u00f3n de la isoforma endotelial e inducible de la no sintasa en h\u00edgado de ratas control. La primera se circunscribe a los territorios vasculares y la segunda al par\u00e9nquima. La expresi\u00f3n permanente de la isoforma inducible la atribuimos a la continua llegada al h\u00edga<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del tratamiento s-adenosilmetionina sobre la fibrosos hep\u00e1tica experimental temprana. papel de \u00f3xido n\u00edtrico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del tratamiento s-adenosilmetionina sobre la fibrosos hep\u00e1tica experimental temprana. papel de \u00f3xido n\u00edtrico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Jose Mesonero Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alejandro Esteller  Perez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Miguel Lopez novoa <\/li>\n<li>angel Sanchez rodriguez (vocal)<\/li>\n<li>Mar\u00eda  Jes\u00fas Tu\u00f1\u00f3n gonz\u00e1lez (vocal)<\/li>\n<li>joaqu\u00edn Garc\u00eda-esta\u00f1 l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jose Mesonero Alvarez La mayor\u00eda de las enfermedades hep\u00e1ticas cr\u00f3nicas se caracterizan por el desarrollo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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