{"id":17175,"date":"2002-01-06T00:00:00","date_gmt":"2002-01-06T00:00:00","guid":{"rendered":""},"modified":"2002-01-06T00:00:00","modified_gmt":"2002-01-06T00:00:00","slug":"alteraciones-de-los-genes-supresores-tumorales-p16-ink4a-p14-arf-y-p53-y-del-reparador-mgmt-en-muestras-citologicas-de-pacientes-con-leucoplasia-y-o-carcinoma-de-celulas-escamosas-implicaciones-en-l","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/alteraciones-de-los-genes-supresores-tumorales-p16-ink4a-p14-arf-y-p53-y-del-reparador-mgmt-en-muestras-citologicas-de-pacientes-con-leucoplasia-y-o-carcinoma-de-celulas-escamosas-implicaciones-en-l\/","title":{"rendered":"Alteraciones de los genes supresores tumorales p16\/ink4a, p14\/arf y p53 y del reparador mgmt en muestras citol\u00f3gicas de pacientes con leucoplasia y\/o carcinoma de c\u00e9lulas escamosas: implicaciones en la carcinog\u00e9nesis oral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00f3nica L\u00f3pez Mart\u00ednez <\/strong><\/h2>\n<p>La alta incidencia del c\u00e1ncer oral en la comunidad aut\u00f3noma del pa\u00eds vasco en comparaci\u00f3n con otros registros espa\u00f1oles, 24,1\/100.000 casos en hombres y 3,1\/100.000 en mujeres, apunta hacia la necesidad de futuras acciones preventivas en este aspecto. En este sentido, la detecci\u00f3n de alteraciones moleculares implicadas en la tumorig\u00e9nesis del c\u00e1ncer oral de c\u00e9lulas escamosas (coce), tales como la inactivaci\u00f3n de los genes supresores tumorales p16\/ink4a, p14\/arf y p53 y del reparador del adn mgmt, podr\u00eda constituir un factor pron\u00f3stico de la evoluci\u00f3n de las lesiones orales premalignas hacia c\u00e1ncer oral. El an\u00e1lisis de muestras citol\u00f3gicas de la cavidad oral en pacientes con lesiones precancerosas y cancerosas ha permitido la detecci\u00f3n de alteraciones en estos genes implicados en la carcinog\u00e9nesis oral. El m\u00e9todo de an\u00e1lisis molecular de las c\u00e9lulas desprendidas de la mucosa oral, desarrollado en este estudio, ha demostrado ser un procedimiento fiable y poco agresivo para la detecci\u00f3n de c\u00e9lulas malignas en pacientes con riesgo de desarrollar un carcinoma de c\u00e9lulas escamosas. Este m\u00e9todo en combinaci\u00f3n con los datos cl\u00ednico-patol\u00f3gicos convencionales en pacientes con riesgo de desarrollar un carcinoma oral puede permitir establecer unos criterios m\u00e1s fiables sobre la actitud terape\u00fatica y pron\u00f3stica de una lesi\u00f3n precancerosa. Del mismo modo, posibilitar\u00eda realizar un mejor seguimiento de los pacientes tratados de un coce.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones de los genes supresores tumorales p16\/ink4a, p14\/arf y p53 y del reparador mgmt en muestras citol\u00f3gicas de pacientes con leucoplasia y\/o carcinoma de c\u00e9lulas escamosas: implicaciones en la carcinog\u00e9nesis oral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones de los genes supresores tumorales p16\/ink4a, p14\/arf y p53 y del reparador mgmt en muestras citol\u00f3gicas de pacientes con leucoplasia y\/o carcinoma de c\u00e9lulas escamosas: implicaciones en la carcinog\u00e9nesis oral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00f3nica L\u00f3pez Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  De Los Angeles Martinez De Pancorbo Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Rivera pomar <\/li>\n<li>isabel Izarzugaza (vocal)<\/li>\n<li>Jes\u00fas Garcia foncillas lopez (vocal)<\/li>\n<li>Miguel angel Gonzalez moles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00f3nica L\u00f3pez Mart\u00ednez La alta incidencia del c\u00e1ncer oral en la comunidad aut\u00f3noma del pa\u00eds vasco en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,940,12909,17],"tags":[53894,53895,13350,13208,3961,53893],"class_list":["post-17175","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-genetica-bioquimica","category-pais-vasco-euskal-herriko-unibertsitatea","category-quimica","tag-isabel-izarzugaza","tag-jesus-garcia-foncillas-lopez","tag-jose-maria-rivera-pomar","tag-maria-de-los-angeles-Martinez-de-pancorbo-gomez","tag-miguel-angel-gonzalez-moles","tag-monica-lopez-Martinez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17175","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17175"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17175\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}