{"id":17183,"date":"2002-03-06T00:00:00","date_gmt":"2002-03-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/induccion-de-tolerancia-al-trasplante-de-islotes-en-ratas-wistar-mediante-celulas-hepaticas\/"},"modified":"2002-03-06T00:00:00","modified_gmt":"2002-03-06T00:00:00","slug":"induccion-de-tolerancia-al-trasplante-de-islotes-en-ratas-wistar-mediante-celulas-hepaticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/induccion-de-tolerancia-al-trasplante-de-islotes-en-ratas-wistar-mediante-celulas-hepaticas\/","title":{"rendered":"Inducci\u00f3n de tolerancia al trasplante de islotes, en ratas wistar, mediante celulas hep\u00e1ticas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Luisa Soto Montenegro <\/strong><\/h2>\n<p>Los objetivos de nuestro trabajo entran dentro de otros m\u00e1s general, que consiste en la b\u00fasqueda de la reversi\u00f3n de las diabetes experimental en ratas, sin la necesidad de utilizar drogas inmunosupresoras. Para ello, partimos de diversos trabajos previos sobre la utilizaci\u00f3n de las c\u00e9lulas de sertoli como inductoras de tolerancia al alo-trasplante de islotes (selawry and cameron, 1993) (korbutt, elliott et al., 1997).  considerando que un sitio de implantaci\u00f3n de los islotes trasplantados suelen ser el h\u00edgado, y que este \u00f3rgano posee ventajas sobre otros sitios de implantaci\u00f3n (ri\u00f1\u00f3n, peritoneo entre otros), pensamos en utilizar c\u00e9lulas hep\u00e1ticas como co-trasplante de islotes, en lugar de las c\u00e9lulas de sertoli empleadas por los grupos de selawry y korbutt. S\u00ed con ello logr\u00e1ramos la facilitaci\u00f3n de la implantaci\u00f3n de los islotes, podr\u00edamos disponer de un medio celular mucho m\u00e1s f\u00e1cilmente asequible y much\u00edsimo m\u00e1s numerosos que las c\u00e9lulas de sertoli.  no hemos encontrado datos bibliogr\u00e1ficos previos, a excepci\u00f3n de los trabajos de ricordi (ricordi, flye et al., 1988) y legrelle (legrelle, chapa, et al., 1993) que se refieren beneficioso de los islotes para la supervivencia de los hepatocitos; y a los trabajos de tafra (tafra, berezniak et al., 1990) y dafoe (dafoe, wang et al., 1992) que se refieren al efecto beneficioso del empleo de tejido fetal hep\u00e1tico sobre la implantaci\u00f3n de islotes fetales en ri\u00f1\u00f3n.  con estos antecedentes, en el proyecto se exponen una serie de experiencias in vitro e in vivo, acerca del objetivo general propuesto: la facilitaci\u00f3n de la tolerancia al alo-trasplante de islotes en ratas, mediante el alo-co-trasplante de c\u00e9lulas hep\u00e1ticas, sin drogas inmunosupresoras.  todas las experiencias afirman el efecto favorable de las c\u00e9lulas hep\u00e1ticas sobre la tolerancia del trasplante de islotes sin drogas inmunosupresoras. sin embargo, el mecanismo no parece ser una interacci\u00f3n celul<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inducci\u00f3n de tolerancia al trasplante de islotes, en ratas wistar, mediante celulas hep\u00e1ticas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inducci\u00f3n de tolerancia al trasplante de islotes, en ratas wistar, mediante celulas hep\u00e1ticas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Luisa Soto Montenegro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Jara Albarran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafaella Dagani balleti <\/li>\n<li>Jos\u00e9 Luis Herrera pombo (vocal)<\/li>\n<li>Alberto Tejedor Jorge (vocal)<\/li>\n<li>Luis felipe Pallardo sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Luisa Soto Montenegro Los objetivos de nuestro trabajo entran dentro de otros m\u00e1s general, que consiste [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[15545,53919,6626,14834,53918,53920],"class_list":["post-17183","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-alberto-tejedor-jorge","tag-antonio-jara-albarran","tag-jose-luis-herrera-pombo","tag-luis-felipe-pallardo-sanchez","tag-m-luisa-soto-montenegro","tag-rafaella-dagani-balleti"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17183"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17183\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}