{"id":17201,"date":"2002-03-06T00:00:00","date_gmt":"2002-03-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-de-nuevos-farmacos-antiangiogenicos\/"},"modified":"2002-03-06T00:00:00","modified_gmt":"2002-03-06T00:00:00","slug":"sintesis-de-nuevos-farmacos-antiangiogenicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-de-nuevos-farmacos-antiangiogenicos\/","title":{"rendered":"Sintesis de nuevos f\u00e1rmacos antiangiogenicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Loreto A\u00f1orbe D\u00edaz <\/strong><\/h2>\n<p>Una de las terapias m\u00e1s prometedoras contra el c\u00e1ncer es la basada en la inhibici\u00f3n de la angiog\u00e9nesis, proceso mediante el cual se forman nuevos capilares sangu\u00edneos a partir de vasos preexistentes en el tejido, siendo la proliferaci\u00f3n y migraci\u00f3n de las c\u00e9lulas endoteliales vasculares una de las etapas m\u00e1s importantes. Esta neovascularizaci\u00f3n permite que lleguen al tumor nutrientes y oxigeno suficientes para que el tumor crezca y se produzcan la invasi\u00f3n y la met\u00e1stasis. En consecuencia, la interrupci\u00f3n del proceso es una diana prometedora de la terapia antitumoral.  el objetivo de esta memoria, ha sido la s\u00edntesis de nuevos inhibidores de la angiog\u00e9nesis como agentes antitumorales y para ello, se han escogido dos estructuras con actividad antiangigo\u00e9nica como modelos: la talidomida y la estaurosporina.  primeramente se han sintetizado una serie de derivados de talidomida, en los que se ha modificado el grupo ftalimido, obteni\u00e9ndose adem\u00e1s los correspondientes amino\u00e1cidos derivados de la hidr\u00f3lisis del anillo de glutarimida y tambi\u00e9n aquellos an\u00e1logos en los que se ha introducido una cadena b\u00e1sica en el nitr\u00f3geno de la glutarimida. Asimismo, se ha llevado a cabo la s\u00edntesis de derivados obtenidos por duplicaci\u00f3n estructural del modelo. Estas modificaciones se han realizado con el fin de conocer su influencia sobre la actividad antiangiog\u00e9nica.  al igual que el modelo los compuestos obtenidos presentan una actividad reguladora bidireccional de la producci\u00f3n de tnf-alfa en c\u00e9lulas hl-60, espec\u00edfica del estimulador empleado.  en segundo lugar, se ha propuesto el dise\u00f1o de nuevos derivados de estaurosporina con actividad antiproliferativa de c\u00e9lulas endoteliales vasculares, se han realizado adem\u00e1s estudios de relaci\u00f3n estructura actividad. Para ello se han sintetizado compuestos estructuralmente m\u00e1s sencillos que el modelo, tanto bisindolilmaleimidas como indolopirrolocarbazoles.  un derivado indoloca<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis de nuevos f\u00e1rmacos antiangiogenicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis de nuevos f\u00e1rmacos antiangiogenicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Loreto A\u00f1orbe D\u00edaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 San pablo-ceu<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Fernandez Bra\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felipe Alcudia gonzalez <\/li>\n<li>marina Gordaliza escobar (vocal)<\/li>\n<li>Antonio Espinosa \u00fabeda (vocal)<\/li>\n<li>marina Moran moset (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Loreto A\u00f1orbe D\u00edaz Una de las terapias m\u00e1s prometedoras contra el c\u00e1ncer es la basada en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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