{"id":17228,"date":"2002-05-06T00:00:00","date_gmt":"2002-05-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-flora-bacteriana-y-de-la-respuesta-inflamatoria-pulmonar-y-sistemica-en-los-pacientes-con-bronquiectasias-estables-cla%c2%adnicamente\/"},"modified":"2002-05-06T00:00:00","modified_gmt":"2002-05-06T00:00:00","slug":"estudio-de-la-flora-bacteriana-y-de-la-respuesta-inflamatoria-pulmonar-y-sistemica-en-los-pacientes-con-bronquiectasias-estables-cla%c2%adnicamente","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-flora-bacteriana-y-de-la-respuesta-inflamatoria-pulmonar-y-sistemica-en-los-pacientes-con-bronquiectasias-estables-cla%c2%adnicamente\/","title":{"rendered":"Estudio de la flora bacteriana y de la respuesta inflamatoria pulmonar y sist\u00e9mica en los pacientes con bronquiectasias estables cl\u00ednicamente"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joaquim Angrill Paxeras <\/strong><\/h2>\n<p>Las broncoquilectasias son una enfermedad bronquial cr\u00f3nica caracterizada por la dilataci\u00f3n anormal bronquial de la luz bronquial. La zona afecta por bronquiectasias presenta una alteraci\u00f3n de los mecanismos de defensa local favoreciendo la ulterior colonizaci\u00f3n bronquial por microorganismos pat\u00f3genos respiratorios (mpps) y la g\u00e9nesis de una respuesta inflamatoria cr\u00f3nica que lejos de eliminar el microorganismo colonizante dar\u00eda lugar a la liberaci\u00f3n de mediadores que generar\u00edan mayor da\u00f1o bronquial, cerrando un c\u00edrculo vicioso de colonizaci\u00f3n, infecci\u00f3n y mayor lesi\u00f3n tisular. Dos aspectos ser\u00edan fundamentales en la patogenia de la enfermedad por un lado la colonizaci\u00f3n bronquial y por otro la respuesta inflamatoria cr\u00f3nica. los dos art\u00edculos en los que se fundamenta esta tesis doctoral intentan responder a algunas de las preguntas sobre la colonizaci\u00f3n y la respuesta inflamatoria pulmonar en pacientes con bronquiectasias en situaci\u00f3n cl\u00ednica estable. El primer estudio evalu\u00f3 la colonizaci\u00f3n bronquial, los factores de riesgo de colonizaci\u00f3n bronquial as\u00ed como valorar el papel diagn\u00f3stico de las diferentes t\u00e9cnicas diagn\u00f3sticas microbiol\u00f3gicas. Los microorganismos m\u00e1s frecuentemente aislados fueron haemophilus influenzae (47%) y pseudomonas spp (24%). Un 305 de los microorganismos aislados presentaban resistencias antibi\u00f3ticas. El cultivo de esputo mostr\u00f3 unas buenas caracter\u00edsticas operativas con una sensibilidad del 69%, especificidad del 86%, valor predictivo positivo del 90% y valor predictivo negativo del 60%. Los factores de riesgo de colonizaci\u00f3n bronquial por mpps fueron:  1,- diagn\u00f3stico de las bronquiectasias antes de los 14v a\u00f1os (odds ratio (or)=3,92, 95%ic 1,29 a 11,95).  2,- fev1 &lt;80% (or=3,91, 95%ic 1,30 a 11,78).  3,- presencia de bronquiectasias varicosas o qu\u00edsticas (or=4,80, 95%ic 1,11 a 21,46).  el segundo de los trabajos evalu\u00f3 la respuesta inflamatoria pulmonar y su relac<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la flora bacteriana y de la respuesta inflamatoria pulmonar y sist\u00e9mica en los pacientes con bronquiectasias estables cl\u00ednicamente<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la flora bacteriana y de la respuesta inflamatoria pulmonar y sist\u00e9mica en los pacientes con bronquiectasias estables cl\u00ednicamente <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joaquim Angrill Paxeras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Torres Mart\u00ed<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Victor Sobradillo Pe\u00f1a <\/li>\n<li>Jordi Dorca Sarlatal (vocal)<\/li>\n<li>Eduardo Mons\u00f3 Molas (vocal)<\/li>\n<li>Javier De Gracia Roldan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joaquim Angrill Paxeras Las broncoquilectasias son una enfermedad bronquial cr\u00f3nica caracterizada por la dilataci\u00f3n anormal bronquial de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,155,9,69,139,384],"tags":[1095,54028,54029,54026,54027,8324],"class_list":["post-17228","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-clinicas","category-ciencias-medicas","category-enfermedades-pulmonares","category-medicina-interna","category-patologia-clinica","tag-antonio-torres-marti","tag-eduardo-monso-molas","tag-javier-de-gracia-roldan","tag-joaquim-angrill-paxeras","tag-jordi-dorca-sarlatal","tag-victor-sobradillo-pena"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17228"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17228\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}