{"id":17283,"date":"2002-07-06T00:00:00","date_gmt":"2002-07-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-epidemiologa%c2%ada-molecular-del-melanoma-maligno-implicacion-del-gen-de-la-tirosinasa-y-del-locus-ink4a-arf\/"},"modified":"2002-07-06T00:00:00","modified_gmt":"2002-07-06T00:00:00","slug":"estudio-de-la-epidemiologa%c2%ada-molecular-del-melanoma-maligno-implicacion-del-gen-de-la-tirosinasa-y-del-locus-ink4a-arf","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-epidemiologa%c2%ada-molecular-del-melanoma-maligno-implicacion-del-gen-de-la-tirosinasa-y-del-locus-ink4a-arf\/","title":{"rendered":"Estudio de la epidemiolog\u00eda molecular del melanoma maligno. implicaci\u00f3n del gen de la tirosinasa y del locus ink4a\/arf."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonio Avellandesa Goicur\u00eda <\/strong><\/h2>\n<p>Se ha estudiado la epidemiolog\u00eda del melanoma en una poblaci\u00f3n espa\u00f1ola (n=158), as\u00ed como la caracterizaci\u00f3n de genes aparentemente implicados (tirosinasa, p14arf y p16ink4a) en la enfermedad. Se trata de un estudio molecular observacional y descriptivo, siguiendo protocolos cl\u00ednicos y moleculares espec\u00edficamente dise\u00f1ados, con objeto de determinar la correlaci\u00f3n entre dichos genes y la evoluci\u00f3n del melanoma para dise\u00f1ar protocolos de identificaci\u00f3n de individuos de alto riesgo para la enfermedad.  los resultados obtenidos han puesto de manifiesto que:  el melanoma de extensi\u00f3n superficial, y con localizaci\u00f3n en tronco, fue mayoritario en la muestra poblacional estudiada, afectando fundamentalmente a personas de edad media con fototipo cut\u00e1neo 3, observ\u00e1ndose una mayor incidencia en mujeres y hasta un 4% de la poblaci\u00f3n estudiada ten\u00eda antecedentes de alg\u00fan miembro familiar con melanoma.  se ha validado un test de rutina para la detecci\u00f3n de melanocitos circulantes mediante el an\u00e1lisis del arn mensajero del gen de la tirosinasa a partir de muestras de sangre perif\u00e9rica, mostrando una elevada sensibilidad, (1 c\u00e9lula melanoc\u00edtica\/ml de sangre). La aplicaci\u00f3n de este test sobre una poblaci\u00f3n de 120 pacientes de melanoma en diferentes estadios de progresi\u00f3n, demostr\u00f3 una fuerte asociaci\u00f3n entre la expresi\u00f3n positiva del test y el estadio cl\u00ednico del paciente. Adem\u00e1s, los pacientes de melanoma en estadios iniciales y con un test positivo para la tirosinasa en sangre, muestran un claro y significativo peor pron\u00f3stico de la enfermedad, evolucionando hacia la generaci\u00f3n de met\u00e1stasis en un plazo inferior a 12 meses, estableciendose por tanto el valor que este test posee como marcador de progresi\u00f3n del melanoma.  la expresi\u00f3n del gen p16ink4a en lesiones de melanoma se pierde de forma directamente proporcional a la desdiferenciaci\u00f3n del tumor, siendo mayor en met\u00e1stasis distales que en adenopat\u00edas primar<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la epidemiolog\u00eda molecular del melanoma maligno. implicaci\u00f3n del gen de la tirosinasa y del locus ink4a\/arf.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la epidemiolog\u00eda molecular del melanoma maligno. implicaci\u00f3n del gen de la tirosinasa y del locus ink4a\/arf. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonio Avellandesa Goicur\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Martin Gallardo Mar\u00eda  Antonia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Monserrat bernal <\/li>\n<li>pablo Luis Ortiz romero (vocal)<\/li>\n<li>paloma S\u00e1nchez-pedre\u00f1o guill\u00e9n (vocal)<\/li>\n<li>Fernando Pinedo moraleda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonio Avellandesa Goicur\u00eda Se ha estudiado la epidemiolog\u00eda del melanoma en una poblaci\u00f3n espa\u00f1ola (n=158), as\u00ed como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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