{"id":17291,"date":"2002-07-06T00:00:00","date_gmt":"2002-07-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/compuestos-fenolicos-de-phagnalon-rupestre-activos-en-hipersensibilidad-y-liberacion-de-mediadores-inflamatorios\/"},"modified":"2002-07-06T00:00:00","modified_gmt":"2002-07-06T00:00:00","slug":"compuestos-fenolicos-de-phagnalon-rupestre-activos-en-hipersensibilidad-y-liberacion-de-mediadores-inflamatorios","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/compuestos-fenolicos-de-phagnalon-rupestre-activos-en-hipersensibilidad-y-liberacion-de-mediadores-inflamatorios\/","title":{"rendered":"Compuestos fenolicos de phagnalon rupestre activos en hipersensibilidad y liberaci\u00f3n de mediadores inflamatorios"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  G\u00f3ngora Carrillo Luis Jes\u00fas <\/strong><\/h2>\n<p>En los seis art\u00edculos que integran la tesis titulada \u00abcompuestos fen\u00f3licos de phagnalon rupestre activos en hipersensibilidad y liberaci\u00f3n de mediadores inflamatorios\u00bb, se aborda, por una parte, el estudio de la modulaci\u00f3n farmacol\u00f3gica de la hipersensibilidad retardada, tanto por contacto como de tipo tubercul\u00ednico, evaluando los efectos que producen dos inhibidores de protein quinasa c. (art\u00edculo: on the activity of trifluoperazine and palmitoylcarnitine in mice: delayed hypersensitivity models. Life sci. 66: 183-188 (2000)).  tras la selecci\u00f3n de dos de los modelos ensayados, se procedi\u00f3 a un estudio fitoqu\u00edmico de la especie phagnalon rupestre, fruto de un proceso de aislamiento guiado por bioensayo. Esta parte result\u00f3 en la publicaci\u00f3n de tres art\u00edculos:  new prenylhydroquinone glycosides from phagnalon rupestre. J. Nat. Prod. 64: 1111-1113 (2001).  phagnalon rupestre as a source of compounds active on contact hypersensitivity. planta med. (2002, en prensa).  phenolic glycosides from phagnalon rupestre. Phytochemistry 59: 857-860 (2002).  en ellos se detalla, dentro de los catorce compuestos aislados de esta especie de distribuci\u00f3n mediterr\u00e1nea y recolectada en la sierra de corbera, el proceso de aislamiento y elucidaci\u00f3n estructural de seis de ellos descritos por primera vez en la naturaleza (cuatro prenilhidroquinonas glucosiladas, una acetofenona benzofur\u00e1nica y un lignano tetrahidrofur\u00e1nico glucosilado), resultando algunos activos en el modelo de hipersensibilidad por contacto.  finalmente se profundiz\u00f3 en el estudio de la actividad antioxidante y antiinflamatoria de algunos de los compuestos fen\u00f3licos aislados, en modelos in vitro. Estos estudios se ven reflejados en dos trabajos:  phenolic methylquinates from phagnalon rupestre are competitive inhibitors of xanthime oxidase and impair lipid peroxidation. Free radic. Res. (Enviado).  effects of caffeoyl conjugates of isoprenyl-hydroquinone glucoside a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Compuestos fenolicos de phagnalon rupestre activos en hipersensibilidad y liberaci\u00f3n de mediadores inflamatorios<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Compuestos fenolicos de phagnalon rupestre activos en hipersensibilidad y liberaci\u00f3n de mediadores inflamatorios <\/li>\n<li><strong>Autor:<\/strong>\u00a0  G\u00f3ngora Carrillo Luis Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Salvador Ma\u00f1ez Ali\u00f1o<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: diego m. Cortes mart\u00ednez <\/li>\n<li> Garc\u00eda gimenez M\u00aa dolores (vocal)<\/li>\n<li>Jos\u00e9 ram\u00f3n Pedro llinares (vocal)<\/li>\n<li> Vila casanova M\u00aa roser (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de G\u00f3ngora Carrillo Luis Jes\u00fas En los seis art\u00edculos que integran la tesis titulada \u00abcompuestos fen\u00f3licos de phagnalon [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,9,189,489,957],"tags":[2514,54207,54205,41583,54206,54208],"class_list":["post-17291","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-ciencias-medicas","category-farmacodinamia","category-farmacognosia","category-farmacologia","tag-diego-m-cortes-Martinez","tag-garcia-gimenez-ma-dolores","tag-gongora-carrillo-luis-jesus","tag-jose-ramon-pedro-llinares","tag-salvador-manez-alino","tag-vila-casanova-ma-roser"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17291"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17291\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}