{"id":17318,"date":"2002-10-06T00:00:00","date_gmt":"2002-10-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/senales-orexigenicas-y-anorexigenicas-durante-la-gestacion\/"},"modified":"2002-10-06T00:00:00","modified_gmt":"2002-10-06T00:00:00","slug":"senales-orexigenicas-y-anorexigenicas-durante-la-gestacion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/senales-orexigenicas-y-anorexigenicas-durante-la-gestacion\/","title":{"rendered":"Se\u00f1ales orexig\u00e9nicas y anorexig\u00e9nicas durante la gestaci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Carmen Garc\u00eda Garc\u00eda <\/strong><\/h2>\n<p>La gestaci\u00f3n es un estado fisiol\u00f3gico caracterizado por un incremento de apetito y volumen de grasa corporal en la madre, asociado con m\u00faltiples cambios neuroendocrinos, aunque los mecanismos que controlan estos procesos son todav\u00eda desconocidos.  la leptina es una hormona secretada principalmente aunque no de forma exclusiva por el tejido adiposo, que regula el peso corporal as\u00ed como el metabolismo energ\u00e9tico. En estos \u00faltimos a\u00f1os se ha demostrado el papel relevante de esta hormona en el control neuroendocrino y de la funci\u00f3n reproductora.  por otra parte, en el hipot\u00e1lamo se expresan distintos neurop\u00e9ptidos y neurotransmisores implicados en el control del peso corporal y la ingesta, entre los que se encuentran: npy (neurop\u00e9ptido y), mch (hormona concentradora de la melanina) y las recientemente descubiertas orexinas. Adem\u00e1s, la prolactina (prl) contribuye significativamente a la reorganizaci\u00f3n del metabolismo y el medio interno de la madre gestante.  por tanto, los objetivos de esta tesis se resumen en los siguientes puntos:  1,- investigar la participaci\u00f3n de la leptina en la regulaci\u00f3n de la ingesta durante la gestaci\u00f3n, estudiando su perfil de expresi\u00f3n y secreaci\u00f3n, as\u00ed como su mecanismo de acci\u00f3n a nivel dentral.  2,- analizar en detalle la regulaci\u00f3n de la expresi\u00f3n hipotal\u00e1mica de npy, mch y prepro-orexina durante la gestaci\u00f3n.  3,- estudiar el papel de la prolactina en la regulaci\u00f3n de estos neurop\u00e9ptidos en la pre\u00f1ez.  los resultados obtenidos en este trabajo nos permiten alcanzar las siguientes conclusiones:  1,- la gestaci\u00f3n en la rata es un estado de hiperleptinemia, con niveles m\u00e1s elevados en leptina en suero durante las primeras horas de la fase nocturna.  2,- la hiperleptinemia presente en la gestaci\u00f3n es producida al menos en parte, por un aumento de expresi\u00f3n de leptina en tejido graso y placenta, y por un incremento en la expresi\u00f3n de la forma soluble transportadora del re<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Se\u00f1ales orexig\u00e9nicas y anorexig\u00e9nicas durante la gestaci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Se\u00f1ales orexig\u00e9nicas y anorexig\u00e9nicas durante la gestaci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Carmen Garc\u00eda Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosa Mar\u00eda Se\u00f1ar\u00eds Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tom\u00e1s Garc\u00eda caballero parada <\/li>\n<li>Manuel Tena sempere (vocal)<\/li>\n<li>Mar\u00eda  del mar Malagon poyato (vocal)<\/li>\n<li>federico Mallo ferrer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Carmen Garc\u00eda Garc\u00eda La gestaci\u00f3n es un estado fisiol\u00f3gico caracterizado por un incremento de apetito y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,3352,2135,817,962,4578,3919,977],"tags":[54291,54289,20998,54290,44383,2892],"class_list":["post-17318","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-fisiologia-del-sistema-nervioso-central","category-fisiologia-endocrina","category-fisiologia-humana","category-genetica","category-ingenieria-genetica","category-neurofisiologia-humana","category-santiago-de-compostela","tag-federico-mallo-ferrer","tag-m-carmen-garcia-garcia","tag-manuel-tena-sempere","tag-maria-del-mar-malagon-poyato","tag-rosa-maria-senaris-rodriguez","tag-tomas-garcia-caballero-parada"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17318"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17318\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}