{"id":17337,"date":"2002-10-06T00:00:00","date_gmt":"2002-10-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-proteinas-hsp27k-hsp70k-y-filamentos-intermedios-en-el-queratacono-avanzado\/"},"modified":"2002-10-06T00:00:00","modified_gmt":"2002-10-06T00:00:00","slug":"estudio-de-las-proteinas-hsp27k-hsp70k-y-filamentos-intermedios-en-el-queratacono-avanzado","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-las-proteinas-hsp27k-hsp70k-y-filamentos-intermedios-en-el-queratacono-avanzado\/","title":{"rendered":"Estudio de las proteinas hsp27k, hsp70k y filamentos intermedios en el queratacono avanzado"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Median Rivero Francisco Jos\u00e9 <\/strong><\/h2>\n<p>Objetivos  1,- revisar nuestra casu\u00edstica.  2,- dado que la respuesta al estr\u00e9s en relaci\u00f3n con las prote\u00ednas hsp27 y hsp70 est\u00e1 condicionada por su posible papel como citoprotector, chaperona en relaci\u00f3n con los filamentos intermedios o de respuesta pretendemos ver la expresi\u00f3n de las mismas en procesos degenerativos de larga evoluci\u00f3n como el queratocono avanzado.  3,- estudio inmunohistoqu\u00edmico y estad\u00edstico de estas prote\u00ednas de estr\u00e9s y los filamentos intermedios en el queratocono avanzado.  material y m\u00e9todo  se utilizan 42 c\u00f3rneas con queratocono y 20 controles. Se realiza estudio histopatol\u00f3gico, morfom\u00e9trico, inmunuhistoqu\u00edmico de las prote\u00ednas hsp27, hps70, ckae1-ae3, vimentina y prote\u00edna s-100. Se realiza estudio estad\u00edstico de los resultados obtenidos.  resultados  se observan alteraciones histopatol\u00f3gicas: adelgazamiento epitelial, alteraci\u00f3n de la polaridad y disminuci\u00f3n del grosor estromal en las c\u00f3rneas con queratocono. La hsp70 se expresa en epitelio, estroma y endotelio corneal. la hsp27 y las citoqueratinas ckae1-ae3 se hallaron a nivel epitelial. la vimentina se detect\u00f3 en estroma y endotelio. Existieron diferencias de expresi\u00f3n entre los dos grupos estudiados, menor en el caso del queratocono, salvo la prote\u00edna s-100 en el epitelio, estroma y endotelio corneal. La hsp27 y las citoqueratinas ckae1-ae3 se hallaron a nivel epitelial. La vimentina se detect\u00f3 en estroma y endotelio. La expresi\u00f3n fue diferente entre los dos grupos, econtr\u00e1ndose disminuida en los queratoconos, salvo la prote\u00edna s-100 en el epitelio del queratocono que result\u00f3 aumentada. el an\u00e1lisis discriminante de la zona central de la c\u00f3rnea de expresi\u00f3n de la intensidad de la hsp70 en el estroma, as\u00ed como de la intensidad de la ckae1-ae3 en el epitelio superficial nos clasifica el 95% de las c\u00f3rneas estudiadas entre controles y queratoconos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las proteinas hsp27k, hsp70k y filamentos intermedios en el queratacono avanzado<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las proteinas hsp27k, hsp70k y filamentos intermedios en el queratacono avanzado <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Median Rivero Francisco Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Cabrera Galv\u00e1n Juan  Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agustin Bullon sopelana <\/li>\n<li>Francisco P\u00e9rez hern\u00e1ndez (vocal)<\/li>\n<li>bonifacio nicol\u00e1s Diaz chico (vocal)<\/li>\n<li>Carlos Pi\u00f1ada darias (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Median Rivero Francisco Jos\u00e9 Objetivos 1,- revisar nuestra casu\u00edstica. 2,- dado que la respuesta al estr\u00e9s en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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