{"id":17363,"date":"2002-11-06T00:00:00","date_gmt":"2002-11-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/absorcion-del-salbutamol-estudios-in-situ-influencia-de-los-procesos-de-secrecion\/"},"modified":"2002-11-06T00:00:00","modified_gmt":"2002-11-06T00:00:00","slug":"absorcion-del-salbutamol-estudios-in-situ-influencia-de-los-procesos-de-secrecion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/absorcion-del-salbutamol-estudios-in-situ-influencia-de-los-procesos-de-secrecion\/","title":{"rendered":"Absorci\u00f3n del salbutamol: estudios \u00abin situ\u00bb. influencia de los procesos de secreci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Belen Valenzuela Jimenez <\/strong><\/h2>\n<p>Se ha dise\u00f1ado un protocolo de ensayos que permitiera profundizar en el conocimiento de los factores que modulan la incorporaci\u00f3n del salbutamol al organismo tras su administraci\u00f3n oral. Para ello se utilizaron distintas t\u00e9cnicas experimentales: perfusi\u00f3n in situ en animales, estudios difusionales en cultivos celulares y determinaci\u00f3n del grado de expresi\u00f3n del gen mdr (portador de secreci\u00f3n intestinal) mediante biolog\u00eda molecular.  se han determinado las constantes aparentes de velocidad de absorci\u00f3n en intestino completo de rata de site concentraciones diferentes de salbutamol, a fin de detectar la linealidad o no linealidad en su absorci\u00f3n.  con salbutamol 0.29 mm (dosis alom\u00e9trica) se ha realizado, en intestino delgado completo de la rata, ensayos de inhibici\u00f3n de sistemas activos de secreci\u00f3n intestinal. Se han utilizado el verapamilo, la azida s\u00f3dica y el zumo de pomelo.  tambi\u00e9n se ha estudiado la constante de velocidad de absorci\u00f3n in situ del salbutamol 0.29 mm, s\u00f3lo y en presencia de verapamilo, en diferentes tramos del intestino delgado de la rata, a fin de establecer diferencias regionales de expresi\u00f3n del sistema secretor. Paralelamente, se ha analizado la expresi\u00f3n del gen mdr en diferentes tejidos, entre los que se encuentran dichos tramos intestinales, con el fin de comprobar si existe una correlaci\u00f3n con los resultados obtenidos in situ.  en los estudios de absorci\u00f3n in vitro se ha determinado la permeabilidad del salbutamol en monocapas celulares de caco2-tc7 y mdck en condiciones similares a las utilizadas para los estudios in situ.  del trabajo realizado se han extra\u00eddo como m\u00e1s relevantes, las siguientes conclusiones:  1,- la t\u00e9cnica de valoraci\u00f3n utilizada para el salbutamol es plenamente satisfactoria dentro del \u00e1mbito de concentraciones ensayadas y justifica su empleo para el fin propuesto.  2,- las constantes aparentes de velocidad de absorci\u00f3n del salbutamol en intestino de rat<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Absorci\u00f3n del salbutamol: estudios \u00abin situ\u00bb. influencia de los procesos de secreci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Absorci\u00f3n del salbutamol: estudios \u00abin situ\u00bb. influencia de los procesos de secreci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Belen Valenzuela Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adela Mart\u00edn Villodr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marina Herraez dominguez <\/li>\n<li>regina L\u00e1zaro gistau (vocal)<\/li>\n<li>domingo Barettino fraile (vocal)<\/li>\n<li>julio Prieto fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Belen Valenzuela Jimenez Se ha dise\u00f1ado un protocolo de ensayos que permitiera profundizar en el conocimiento de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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