{"id":17389,"date":"2002-12-06T00:00:00","date_gmt":"2002-12-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacocinetico-poblacional-de-vancomicina-en-neonatos\/"},"modified":"2002-12-06T00:00:00","modified_gmt":"2002-12-06T00:00:00","slug":"estudio-farmacocinetico-poblacional-de-vancomicina-en-neonatos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacocinetico-poblacional-de-vancomicina-en-neonatos\/","title":{"rendered":"Estudio farmacocin\u00e9tico poblacional de vancomicina en neonatos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Marqu\u00e9s Mi\u00f1ana M. Remedios <\/strong><\/h2>\n<p>El estudio se realiz\u00f3 con el fin de caracterizar los par\u00e1metros farmacocin\u00e9ticos de la vancomicina en neonatos y valorar la relaci\u00f3n entre dichos par\u00e1metros y las caracter\u00edsticas antropom\u00e9tricas y\/o farmacol\u00f3gicas, as\u00ed como dise\u00f1ar reg\u00edmenes de dosificaci\u00f3n espec\u00edficos en funci\u00f3n de modelos farmacocin\u00e9ticos basados en las relaciones entre los par\u00e1metros farmacocin\u00e9ticos y las convariables antropom\u00e9tricas y\/o farmacol\u00f3gicas. La poblaci\u00f3n de estudio fue de 70 neonatos, con un amplio rango de edad gest\u00e1cional y peso, que presentaban infecci\u00f3n a sepsis por microorganismos grampositivos por lo que se les administr\u00f3 vancomicina, monitoriz\u00e1ndose posteriormente los niveles s\u00e9ricos del antibi\u00f3tico. la valoraci\u00f3n de la vancomicina en suero se realizo mediante la t\u00e9cnica anal\u00edtica de inmunoensayo  de polarizaci\u00f3n fluorescente. En el modelo farmacoestad\u00edstico, se seleccion\u00f3 como modelo estructural intraindividual el modelo monocompartimental de dosis m\u00faltiples y la obtenci\u00f3n del modelo estructural interindividual se realizo mediante dos procedimientos. En el procedimiento 1, se estimaron los par\u00e1metros farmacocin\u00e9ticos poblacionales mediante el m\u00e9todo est\u00e1ndar en dos etapas y en el procedimiento 2 mediante el modelo no lineal de efectos mixtos, utiliz\u00e1ndose estos valores obtenidos en cada procedimiento para la estimaci\u00f3n de los par\u00e1metros farmacocin\u00e9ticos individuales por regresi\u00f3n bayesiana y seguidamente estos par\u00e1metros se utilizaron para la detecci\u00f3n de covariables significativas. El aclaramiento de la vancomicina normalizado para el peso, aumenta con la edad postoconcepcional y con la administraci\u00f3n concomitante de miadazolam o de amoxicilina-clavul\u00e1nico, mientras que la administraci\u00f3n de dopamina los disminuye. El volumen de distribuci\u00f3n de la vancomicina normalizado para el peso, no esta correlacionado con ninguna covariable antropom\u00e9trica. El valor de este par\u00e1metro aumenta con la administraci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocin\u00e9tico poblacional de vancomicina en neonatos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocin\u00e9tico poblacional de vancomicina en neonatos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Marqu\u00e9s Mi\u00f1ana M. Remedios <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Esteban Peris Ribera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Moreno frigols <\/li>\n<li>mercedes Fern\u00e1ndez ar\u00e9valo (vocal)<\/li>\n<li>Jos\u00e9 ignacio Fernandez de troconiz (vocal)<\/li>\n<li> Escriv\u00e1 mu\u00f1oz Juan  Jos\u00e9 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marqu\u00e9s Mi\u00f1ana M. Remedios El estudio se realiz\u00f3 con el fin de caracterizar los par\u00e1metros farmacocin\u00e9ticos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9481,155,9,189,161],"tags":[27331,11841,51407,3421,54475,54476],"class_list":["post-17389","post","type-post","status-publish","format-standard","hentry","category-absorcion-de-los-farmacos","category-ciencias-clinicas","category-ciencias-medicas","category-farmacodinamia","category-pediatria","tag-escriva-munoz-juan-jose","tag-jose-esteban-peris-ribera","tag-jose-ignacio-fernandez-de-troconiz","tag-jose-luis-moreno-frigols","tag-marques-minana-m-remedios","tag-mercedes-fernandez-arevalo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17389"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17389\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}