{"id":17400,"date":"2002-12-06T00:00:00","date_gmt":"2002-12-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/deaferentacion-neuronal-reversible-en-el-sistema-nervioso-central-adulto-inducida-por-neurotoxina-tetanica\/"},"modified":"2002-12-06T00:00:00","modified_gmt":"2002-12-06T00:00:00","slug":"deaferentacion-neuronal-reversible-en-el-sistema-nervioso-central-adulto-inducida-por-neurotoxina-tetanica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/deaferentacion-neuronal-reversible-en-el-sistema-nervioso-central-adulto-inducida-por-neurotoxina-tetanica\/","title":{"rendered":"Deaferentaci\u00f3n neuronal reversible en el sistema nervioso central adulto inducida por neurotoxina tetanica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Gonzalez Forero <\/strong><\/h2>\n<p>En este trabajo se ha utilizado la neurotoxina tet\u00e1nica (txte) como herramienta para inducir deaferentaci\u00f3n sin\u00e1ptica no lesiva en el sistema nervioso central. Modelos experimentales relacionados han empleado aproximaciones que implican una lesi\u00f3n f\u00edsica directa de las fibras aferentes. La axotom\u00eda, la denervaci\u00f3n funcional perif\u00e9rica, o la p\u00e9rdida selectiva de la diana, inducen una deaferentaci\u00f3n parcial, caracterizada por la retracci\u00f3n de terminales sin\u00e1pticos sobre la membrana somatodendr\u00edtica. No obstante, en estos casos resulta dif\u00edcil discernir entre los efectos causados por la deaferentaci\u00f3n, los resultantes de la desconexi\u00f3n de la diana en el mantenimiento y estabilidad de las conexiones presin\u00e1pticas. Poco se conoce, sin embargo, acerca del papel que tiene la conectividad, composici\u00f3n y actividad sin\u00e1ptica aferente, en el mantenimiento del fenotipo y de las propiedades fisiol\u00f3gicas y morfol\u00f3gicas neuronales, as\u00ed como de la respuesta y mecanismo de plasticidad que exhiben cuando estos par\u00e1metros se modifican. como modelo experimental se ha utilizado el n\u00facleo del motor ocular externo (nmoe), cuya fisiolog\u00eda y conectividad se conocen. Adem\u00e1s previamente se ha estudiado la respuesta de las neuronas del nmoe a la p\u00e9rdida de conectividad eferente, bien mediante axotom\u00eda, denervaci\u00f3n funcional mediante toxina botul\u00ednica txbo o ablaci\u00f3n selectiva de la diana. En este trabajo se han  caracterizado los efectos del bloqueo funcional de la transmisi\u00f3n sin\u00e1ptica aferente sobre las propiedades de disparo y la sinaptolog\u00eda en neuronas del nmoe. Asimismo, se estudiaron las relaciones entre balance de actividad sin\u00e1ptica, modulado mediante diferentes dosis de txte, y el estado funcional, fenotipo o variabilidad en el disparo de las neuronas del nmoe.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Deaferentaci\u00f3n neuronal reversible en el sistema nervioso central adulto inducida por neurotoxina tetanica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Deaferentaci\u00f3n neuronal reversible en el sistema nervioso central adulto inducida por neurotoxina tetanica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Gonzalez Forero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pablo de olavide<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Pastor Loro Angel Manuel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan m.v. Blasi cab\u00fas <\/li>\n<li>Antonio Rodr\u00edguez moreno (vocal)<\/li>\n<li>Miguel Escudero gonzalez (vocal)<\/li>\n<li> Dom\u00ednguez del toro eduardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Gonzalez Forero En este trabajo se ha utilizado la neurotoxina tet\u00e1nica (txte) como herramienta para inducir [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8036,35,1632,3352,817,4275,4274,37286,226],"tags":[54504,54502,54506,20203,54505,54503],"class_list":["post-17400","post","type-post","status-publish","format-standard","hentry","category-biofisica","category-ciencias-de-la-vida","category-comportamiento-animal","category-fisiologia-del-sistema-nervioso-central","category-fisiologia-humana","category-neurociencias","category-neurofisiologia","category-pablo-de-olavide","category-zoologia","tag-antonio-rodriguez-moreno","tag-david-gonzalez-forero","tag-dominguez-del-toro-eduardo","tag-joan-m-v-blasi-cabus","tag-miguel-escudero-gonzalez","tag-pastor-loro-angel-manuel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17400"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17400\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}