{"id":17407,"date":"2018-03-09T09:05:27","date_gmt":"2018-03-09T09:05:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-cristalografico-de-enzimas-del-ciclo-de-la-metionina-estructura-y-funcion\/"},"modified":"2018-03-09T09:05:27","modified_gmt":"2018-03-09T09:05:27","slug":"analisis-cristalografico-de-enzimas-del-ciclo-de-la-metionina-estructura-y-funcion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analisis-cristalografico-de-enzimas-del-ciclo-de-la-metionina-estructura-y-funcion\/","title":{"rendered":"An\u00e1lisis cristalogr\u00e1fico de enzimas del ciclo de la metionina: estructura y funci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Gonz\u00e1lez P\u00e9rez <\/strong><\/h2>\n<p>En este trabajo se presenta el estudio estructural mediante la t\u00e9cnica de difracci\u00f3n de rayos x de dos prote\u00ednas implicadas en el ciclo de la metionina (mat y bhmt, ambas de h\u00edgado de rata).  mat (atp: metionina adenosiltransferasa) cataliza la s\u00edntesis de sam (s-adenosilmetionina), el compuesto donador de metilos m\u00e1s importante del organismo. En esta tesis se presenta la estructura tridimensional de esta enzima, as\u00ed como la de varios complejos de mat con su substratos o an\u00e1logos de los mismos. Con todos los resultados obtenidos, se propone un mecanismo de reacci\u00f3n enzim\u00e1tica para mat, apoyado en un gran n\u00famero de datos experimentales.  bhmt (beta\u00edna: homociste\u00edna metiltransferasa), cataliza la s\u00edntesis de metionina. En esta tesis se presentan numerosos resultados de cristalizaci\u00f3n y se describe la aplicaci\u00f3n de diferentes t\u00e9cnicas de cristalograf\u00eda para la resoluci\u00f3n de su estructura. Tambi\u00e9n se detalla el procedimiento seguido para la obtenci\u00f3n de un modelo de bhmt que aporta informaci\u00f3n muy valiosa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis cristalogr\u00e1fico de enzimas del ciclo de la metionina: estructura y funci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis cristalogr\u00e1fico de enzimas del ciclo de la metionina: estructura y funci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Gonz\u00e1lez P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juliana Sanz Aparicio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rosalia Rodr\u00edguez Garc\u00eda <\/li>\n<li> Pajares taranc\u00f3n M\u00aa de los angeles (vocal)<\/li>\n<li>mart\u00edn Mart\u00ednez ripoll (vocal)<\/li>\n<li>margarita Menendez fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Gonz\u00e1lez P\u00e9rez En este trabajo se presenta el estudio estructural mediante la t\u00e9cnica de difracci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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