{"id":17492,"date":"2018-03-09T09:05:35","date_gmt":"2018-03-09T09:05:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/contribucion-de-cd3gamma-a-la-regulacion-y-funcion-del-complejo-tcr-cd3-en-linfocitos-t-humanos-maduros\/"},"modified":"2018-03-09T09:05:35","modified_gmt":"2018-03-09T09:05:35","slug":"contribucion-de-cd3gamma-a-la-regulacion-y-funcion-del-complejo-tcr-cd3-en-linfocitos-t-humanos-maduros","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/contribucion-de-cd3gamma-a-la-regulacion-y-funcion-del-complejo-tcr-cd3-en-linfocitos-t-humanos-maduros\/","title":{"rendered":"Contribuci\u00f3n de cd3gamma a la regulaci\u00f3n y funci\u00f3n del complejo tcr\/cd3 en linfocitos t humanos maduros"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Serrano Torres <\/strong><\/h2>\n<p>El receptor para ant\u00edgeno de la c\u00e9lula t(alfa,beta) (complejo tcr\/cd3) es una estructura multiproteica de estequiometr\u00eda desconocida integrada por las cadenas variables tcr (tcralfa y tcrbeta), responsables del reconocimiento de ant\u00edgeno, y las cadenas invariantes cd3 (cd3*, cd3gamma, cd3* y cd3*), responsables del ensamblaje-expresi\u00f3n del complejo y de la se\u00f1alizaci\u00f3n intracelular. Su estructura global &#8211; m\u00ednima alfabeta,&#8212;&#8212;- se supone compartida por todas las c\u00e9lulas talfabeta, cd4+ y cd8+. Sin embargo, el papel fisiol\u00f3gico de cada una de las cadenas invariantes es a\u00fan desconocido, y es tema de debate si sus funciones son redundantes o espec\u00edficas. El estudio de mutantes (naturales o inducidos, rat\u00f3n o humanos) constituye una \u00fatil aproximaci\u00f3n para el esclarecimiento de estas cuestiones. En este trabajo se analiza desde m\u00faltiples puntos de vista (fenot\u00edpico, funcional y bioqu\u00edmico), en modelos desarrollados in vitro (linfocitos t inmortalizados con herpesvirus saimiri), un caso de inmunodeficiencia humana de cd3gamma. los resultados:  1,- confirmar que la cadena cd3gamma tiene un papel especializado en la construcci\u00f3n de complejos tcr\/cd3 en el linaje cd8+ respecto al cd4+ (da zapata et al j.Biol. Chem. 274, 35119-35128, 1999).  2,- sugieren que, adem\u00e1s, podr\u00eda existir una implicaci\u00f3n funcional de la cadena cd3gamma, para determinados trabajos como la producci\u00f3n de il2 (pacheco-casto y cols. 1998), la modulaci\u00f3n mediada por pma, la polarizaci\u00f3n, o la apoptosis se encuentran afectados en ausencia de cd3gamma, pero no para otros como la citolisis, la proliferaci\u00f3n, la s\u00edntesis de tnfalfa (pacheco-castro y cols. 1998). Sin embargo, cd3gamma contribuir\u00eda para ajustar cin\u00e9ticamente otras funciones como la din\u00e1mica basal, modulaci\u00f3n mediada por ligandos, la fosforilaci\u00f3n o los cambios en la expresi\u00f3n de mol\u00e9culas de membrana. Estos resultados funcionales y otros obtenidos en los modelos k.O de las cadenas<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Contribuci\u00f3n de cd3gamma a la regulaci\u00f3n y funci\u00f3n del complejo tcr\/cd3 en linfocitos t humanos maduros<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Contribuci\u00f3n de cd3gamma a la regulaci\u00f3n y funci\u00f3n del complejo tcr\/cd3 en linfocitos t humanos maduros <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Serrano Torres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ramon Regueiro  Gonzalez Barros<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Martinez naves <\/li>\n<li>Andr\u00e9s Alcover santos (vocal)<\/li>\n<li> Rojo hern\u00e1ndez Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Manuel Guzm\u00e1n pastor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Serrano Torres El receptor para ant\u00edgeno de la c\u00e9lula t(alfa,beta) (complejo tcr\/cd3) es una estructura multiproteica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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