{"id":17531,"date":"2018-03-09T09:05:38","date_gmt":"2018-03-09T09:05:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-respuesta-inmune-humoral-post-trasplante-renal-rechazo-agudo-humoral\/"},"modified":"2018-03-09T09:05:38","modified_gmt":"2018-03-09T09:05:38","slug":"estudio-de-la-respuesta-inmune-humoral-post-trasplante-renal-rechazo-agudo-humoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-respuesta-inmune-humoral-post-trasplante-renal-rechazo-agudo-humoral\/","title":{"rendered":"Estudio de la respuesta inmune humoral post-trasplante renal: rechazo agudo humoral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Crespo Barrio <\/strong><\/h2>\n<p>El efecto delet\u00e9ro de la presencia de anticuerpos anti-hla donante-espec\u00edfico (ads) pre-trasplante renal en la supervivencia del injerto a corto plazo qued\u00f3 patente en las primeras experiencias cl\u00ednicas en los a\u00f1os 60. Sin embargo, resulta controvertido el papel que juegan los ads anti-hla que aparecen post-trasplante. La experiencia preliminar de nuestro grupo de trabajo y de otros suguiere que la aparici\u00f3n de ads post-trasplante renal se relaciona con el desarrollo de un episodio de rechazo agudo de caracter\u00edsticas diferenciadas. Dise\u00f1amos los estudios que componen esta tesis con objeto de definir adecuadamente el rechazo agudo humoral o rechazo agudo asociado a la aparici\u00f3n de ads, as\u00ed como determinar su incidencia, caracter\u00edsticas cl\u00ednicas, serol\u00f3gicas e histol\u00f3gicas, y valorar la eficacia de una propuesta terap\u00e9utica alternativa. La poblaci\u00f3n del estudio la componen los enfermos que recibieron un trasplante renal en el massachusetts general hospital de boston entre julio de 1995 y julio de 1999 (n=232). Revisamos la evoluci\u00f3n cl\u00ednica de los 81 receptores que hab\u00edan sufrido alg\u00fan episodio de rechazo agudo durante los tres primeros meses post-trasplante; realizamos pruebas cruazadas donante-espec\u00edficas con los sueros peri-rechazo; examinamos las caracter\u00edsticas histol\u00f3gicas de las biopsias correspondientes y utilizamos t\u00e9cnicas de inmunofluorescencia para evaluar la presencia de dep\u00f3sitos de la fracci\u00f3n c4d del complemento en tejido congelado.  las conclusiones fundamentales de nuestros estudios son las siguientes:  1,- el rechazo agudo humoral es una entidad cl\u00ednica y patol\u00f3gica diferenciada que podemos diagnosticar con criterios cl\u00ednicos: disfunci\u00f3n renal severa precoz t\u00edpicamente c\u00f3rtico-resistente y con frecuencia resistente al tratamiento anti-linfocitario convencional; serol\u00f3gicos: acompa\u00f1ada de la aparici\u00f3n de anticuerpos donantes-espec\u00edficos en el momento del rechazo, habitualmente igg anti-h<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la respuesta inmune humoral post-trasplante renal: rechazo agudo humoral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la respuesta inmune humoral post-trasplante renal: rechazo agudo humoral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Crespo Barrio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>A. Pascual Manuel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Ortu\u00f1o mirete <\/li>\n<li>Manuel Arias rodriguez (vocal)<\/li>\n<li>manel Sole arqu\u00e9s (vocal)<\/li>\n<li>josep Mar\u00eda Griny\u00f3 boira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Crespo Barrio El efecto delet\u00e9ro de la presencia de anticuerpos anti-hla donante-espec\u00edfico (ads) pre-trasplante renal en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,35,9,1737,139,179,2953],"tags":[54833,14928,48992,54834,21611,54832],"class_list":["post-17531","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-de-la-vida","category-ciencias-medicas","category-inmunologia","category-medicina-interna","category-nefrologia","category-trasplante-de-organos","tag-a-pascual-manuel","tag-joaquin-ortuno-mirete","tag-josep-maria-grinyo-boira","tag-manel-sole-arques","tag-manuel-arias-rodriguez","tag-marta-crespo-barrio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17531"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17531\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}