{"id":17553,"date":"2018-03-09T09:05:40","date_gmt":"2018-03-09T09:05:40","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-protea%c2%adna-omega-del-plasmido-psm19035-es-un-regulador-global-que-controla-replicacion-y-segregacion-plasmidica\/"},"modified":"2018-03-09T09:05:40","modified_gmt":"2018-03-09T09:05:40","slug":"la-protea%c2%adna-omega-del-plasmido-psm19035-es-un-regulador-global-que-controla-replicacion-y-segregacion-plasmidica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/la-protea%c2%adna-omega-del-plasmido-psm19035-es-un-regulador-global-que-controla-replicacion-y-segregacion-plasmidica\/","title":{"rendered":"La prote\u00edna omega del plasmido psm19035 es un regulador global que controla replicaci\u00f3n y segregaci\u00f3n plasmidica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Belen De La Hoz Rastrollo <\/strong><\/h2>\n<p>El pl\u00e1smido de bajo n\u00famero de copias y amplio rango de hu\u00e9sped psm19035 de streptococcus pyogenes codifica una prote\u00edna de 71 aa, que recibe el nombre de omega, la cual regula la replicaci\u00f3n y la segregaci\u00f3n del pl\u00e1smido. dicho gen se encuentra ubicado entre los g\u00e9nes *y*, formando parte del oper\u00f3n ***.  la prote\u00edna omega reprime, tanto in vivo como in vitro, la transcripci\u00f3n desde los promotores pcops, p* y pomega. Cuando el gen omega est\u00e1 presente en una c\u00e9lula, la cual porta un minireplicaci\u00f3n que contiene la regi\u00f3n rep del pl\u00e1smido psm19035, el n\u00famero de copias de este se ve incrementado. esto es debido a la represi\u00f3n del gen cops, cuyo producto regula negativamente la replicaci\u00f3n. La prote\u00edna omega est\u00e1 involucrada en la segregaci\u00f3n y el mantenimiento del pl\u00e1smido en la progenie, mediante la regulaci\u00f3n negativa de los genes *,* y*.  la prote\u00edna omega inhibe la expresi\u00f3n de los genes cops, * y omega, sin impedir que *a rnap de b.Subtilis interacione con las secuencias promotoras . Ambas prote\u00ednas permanecen unidas al adn, vi\u00e9ndose aumentada la afinidad de omera por el adn cuando la *a rnap est\u00e1 acomplejada con este.  la prote\u00edna omega, que pertenece a la superfamilia arc\/metj, es un &#8212; en soluci\u00f3n. La prote\u00edna omega posee un nh2-terminal flexible y un dominio rhh (1 mina-h\u00e9lice-h\u00e9lice). Las dos alfa -h\u00e9lices de cada &#8212; forman un n\u00facleo hidrof\u00f3bico, mientras que las dos 1 minas-beta en orientaci\u00f3n antiparalela quedan en la superficie, siendo este el dominio de interacci\u00f3n con el adn, a trav\u00e9s del surco mayor.  la estructura secundaria de omega no se ve afectada por variaciones en la fuerza i\u00f3nica, pero un incremento en la concentraci\u00f3n de sal si aumenta su estabilidad tanto t\u00e9rmica como a agentes caotr\u00f3picos. La desnaturalizaci\u00f3n de omega es frecuentemente dependiente de la concentraci\u00f3n de prote\u00edna, tal y como cabr\u00eda esperar para prote\u00ednas que oligomerizan. A su vez la estabilidad t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La prote\u00edna omega del plasmido psm19035 es un regulador global que controla replicaci\u00f3n y segregaci\u00f3n plasmidica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La prote\u00edna omega del plasmido psm19035 es un regulador global que controla replicaci\u00f3n y segregaci\u00f3n plasmidica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Belen De La Hoz Rastrollo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos Alonso Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: margarita Salas falgueras <\/li>\n<li>ram\u00f3n Daz oreja (vocal)<\/li>\n<li>victor De lorenzo prieto (vocal)<\/li>\n<li>Fernando Rojo de castro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Belen De La Hoz Rastrollo El pl\u00e1smido de bajo n\u00famero de copias y amplio rango de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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