{"id":17587,"date":"2018-03-09T09:05:43","date_gmt":"2018-03-09T09:05:43","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-funcional-del-gen-muscleblind-valoracion-de-drosophila-como-modelo-para-el-estudio-de-la-distrofia-miotonica\/"},"modified":"2018-03-09T09:05:43","modified_gmt":"2018-03-09T09:05:43","slug":"caracterizacion-funcional-del-gen-muscleblind-valoracion-de-drosophila-como-modelo-para-el-estudio-de-la-distrofia-miotonica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-funcional-del-gen-muscleblind-valoracion-de-drosophila-como-modelo-para-el-estudio-de-la-distrofia-miotonica\/","title":{"rendered":"Caracterizaci\u00f3n funcional del gen muscleblind: valoraci\u00f3n de drosophila como modelo para el estudio de la distrofia miot\u00f3nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda Casado M. Zaida <\/strong><\/h2>\n<p>Durante el desarrollo embrionario mbl es necesario para la formaci\u00f3n de un patr\u00f3n muscular correcto, en concreto para la formaci\u00f3n de las bandas z de los sarc\u00f3meros y las uniones indirectas del m\u00fasculo a la epidermis. adem\u00e1s, el gen mbl tambi\u00e9n es requerido para la diferenciaci\u00f3n tard\u00eda de los fotocorrectores.  por otro lado, se han identificado hasta tres genes hom\u00f3logos a mbl en humanos (mbnl, mbll y mbxl), todos ellos relacionados con el desarrollo de la distrof\u00eda miot\u00f3nica (dm), la distrof\u00eda muscular m\u00e1s com\u00fan en adultos.  los principales objetivos de esta tesis doctoral son profundizar en la caracterizaci\u00f3n funcional del gen mbl, analizando su papel durante el desarrollo de drosophila, y valorar la utilidad de drosophila como modelo de estudio de la distrofia miot\u00f3nica. En concreto, se pretende, por un lado, el estudio del efecto de la expresi\u00f3n ect\u00f3pica de mbl en diferentes tejidos y estadios del desarrollo, y por otro, evaluar la homolog\u00eda funcional con su hom\u00f3logo humano mbnl. Para ello se va a utilizar el sistema uas-gal4 empleando moscas transg\u00e9nicas para las construcciones uas-mbl y uas-mbnl obtenidas mediante microinyecci\u00f3n.  otro objetivo del trabajo es el estudio de relaciones epist\u00e1ticas de mbl con una serie de genes candidatos seleccionados en funci\u00f3n de sus fenotipos y patrones de expresi\u00f3n.  tambi\u00e9n se pretende completar el estudio del patr\u00f3n de expresi\u00f3n del gen en los diferentes discos imaginables de drosophila as\u00ed como su posible funci\u00f3n en estos tejidos, recurriendo a la obtenci\u00f3n de clones mutantes para nuestro gen por recombinaci\u00f3n mi\u00f3tica.  con todo esto se espera conseguir una informaci\u00f3n completa y detallada del papel de mbl en el desarrollo de drosophila, y por extensi\u00f3n en otros organismos que conserven los mismos patrones de desarrollo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n funcional del gen muscleblind: valoraci\u00f3n de drosophila como modelo para el estudio de la distrofia miot\u00f3nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n funcional del gen muscleblind: valoraci\u00f3n de drosophila como modelo para el estudio de la distrofia miot\u00f3nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda Casado M. Zaida <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel P\u00e9rez Alonso<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: sonsoles Campuzano corrales <\/li>\n<li>pablo Couso Juan (vocal)<\/li>\n<li>Francisco Palau (vocal)<\/li>\n<li>ibo Galindo m\u00e1ximo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda Casado M. Zaida Durante el desarrollo embrionario mbl es necesario para la formaci\u00f3n de un patr\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,35,962,37365,17],"tags":[54985,54981,54986,54982,54984,54983],"class_list":["post-17587","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-genetica","category-genetica-del-desarrollo","category-quimica","tag-francisco-palau","tag-garcia-casado-m-zaida","tag-ibo-galindo-maximo","tag-manuel-perez-alonso","tag-pablo-couso-juan","tag-sonsoles-campuzano-corrales"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17587"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17587\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}