{"id":17613,"date":"2018-03-09T09:05:46","date_gmt":"2018-03-09T09:05:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-las-catecolaminas-sobre-las-arritmias-inducidas-por-isquemia-miocardica\/"},"modified":"2018-03-09T09:05:46","modified_gmt":"2018-03-09T09:05:46","slug":"efecto-de-las-catecolaminas-sobre-las-arritmias-inducidas-por-isquemia-miocardica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-las-catecolaminas-sobre-las-arritmias-inducidas-por-isquemia-miocardica\/","title":{"rendered":"Efecto de las catecolaminas sobre las arritmias inducidas por isquemia mioc\u00e1rdica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Lopez Vidal <\/strong><\/h2>\n<p>Las catecolaminas son agentes intr\u00f3picos que se utilizan en el tratamiento de una gran variedad de patolog\u00edas como el shock s\u00e9ptico y el cardiog\u00e9nico. sin embargo, su papel en las arritmias cardiacas inducidas por isquemia mioc\u00e1rdica es muy controvertido. Nuestros objetivos concretos han sido evaluar los efectos pro o antiarr\u00edtmicos de la catecolaminas (noradrenalina, dopamina, dobutamina y dopexamina), en un modelo \u00abin vivo\u00bb de inducci\u00f3n de arritmias por isquemia mioc\u00e1rdica (ligadura de la arteria coronaria); estudiar los efectos hemodin\u00e1micos de estos f\u00e1rmacos en la fase aguda de la isquemia mioc\u00e1rdica y la mortalidad que originan; cuantificar los niveles tisulares de ampc y gmpc, en ventr\u00edculo izquierdo (isqu\u00e9mico) y ventriculo derecho (control); analizar el papel que desempe\u00f1an los nucle\u00f3tidos c\u00edclicos en los efectos pro o antiarr\u00edtmicos inducidos por las catecolaminas e investigar las posibles consecuencias de asociar distintas catecolaminas (las asociaciones que se han utilizado son dopamina, dobutamina y dopexamina m\u00e1s noradrenalina). para cumplir estos objetivos hemos utilizado un modelo de producci\u00f3n de arritmias por oclusi\u00f3n coronaria. Se emplearon ratas sd, a las que se anestesi\u00f3 con pentobarbital intraperitoneal, realiz\u00e1ndose a continuaci\u00f3n una traqueotom\u00eda para garantizar su adecuada oxigenaci\u00f3n, se les canaliz\u00f3 la arteria car\u00f3tida izquierda con el fin de obtener un registro continuo de presi\u00f3n arterial y la vena femoral izquierda para infundir los f\u00e1rmacos a estudio. Para acceder a la arteria coronaria izquierda, realizamos una toracotom\u00eda, volteamos el coraz\u00f3n y pasamos la ligadura.  el experimento se incluy\u00f3 en el estudio si tras un periodo de estabilizaci\u00f3n cumplia unos requisitos previos. Se registr\u00f3 ecg y pa con condiciones basales, tras 15 min. Postinfusi\u00f3n y de forma continua durante 30 min., Tras la ligadura, separando por un lado el v.I y por otro el v.D mediante r.I.A. los f\u00e1rmaco<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de las catecolaminas sobre las arritmias inducidas por isquemia mioc\u00e1rdica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de las catecolaminas sobre las arritmias inducidas por isquemia mioc\u00e1rdica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Lopez Vidal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Dolores Carceles Baron<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda victoria Milan\u00e9s maquil\u00f3n <\/li>\n<li>Fernando Miralles pardo (vocal)<\/li>\n<li>f\u00e9lix L\u00f3pez rodr\u00edguez (vocal)<\/li>\n<li>Emilio Carrillo ruiperez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Lopez Vidal Las catecolaminas son agentes intr\u00f3picos que se utilizan en el tratamiento de una gran [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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