{"id":17669,"date":"2018-03-09T09:05:50","date_gmt":"2018-03-09T09:05:50","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/role-of-oxidative-stress-in-the-vascular-dysfunction-related-to-hypertension-and-aging\/"},"modified":"2018-03-09T09:05:50","modified_gmt":"2018-03-09T09:05:50","slug":"role-of-oxidative-stress-in-the-vascular-dysfunction-related-to-hypertension-and-aging","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/role-of-oxidative-stress-in-the-vascular-dysfunction-related-to-hypertension-and-aging\/","title":{"rendered":"Role of oxidative stress in the vascular dysfunction related to hypertension and aging"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Edith-clara Garc\u00eda Cohen <\/strong><\/h2>\n<p>Los radicales libres derivados del ox\u00edgeno y los derivados de peroxidaci\u00f3n lip\u00eddica juegan un importante papel patog\u00e9nico en enfermedades con elevada incidencia cl\u00ednica como la hipertensi\u00f3n y en los cambios fisiol\u00f3gicos que acompa\u00f1an al proceso de envejecimiento, ambas situaciones asociadas a estr\u00e9s oxidativo, disfunci\u00f3n vascular y elevados niveles plasm\u00e1ticos de peroxidaci\u00f3n lip\u00eddica.  nosostros nos planteamos estudiar la acci\u00f3n que derivados de peroxidaci\u00f3n lip\u00eddica, tales como el tert-butil hidroper\u00f3xido (t-booh), puedan ejercer a nivel de la pared vascular, as\u00ed como el papel que estos agentes inductores de estr\u00e9s oxidativo juegan en el incremento de las resistencias vasculares perif\u00e9ricas que caracterizan al envejecimiento y, sobre todo, a la hipertensi\u00f3n.  para ello, analizamos:  1,- las alteraciones que t-booh puede producir en la regulaci\u00f3n del tono vasomotor y sobre la funcionalidad de la maquinaria contr\u00e1ctil en las arterias de ratas normotensas, wistar-kyoto (wky), y de ratas espont\u00e1neamente hipertensas (shr) de 6, 18 y 24 meses de edad.  2,- la influencia de la edad, la hipertensi\u00f3n y el endotelio sobre la vasoconstricci\u00f3n inducida por t-booh.  3,- los mecanismos responsables de la vasoconstricci\u00f3n inducida por t-booh en ratas normo e hipertensas.  4,- la influencia de agentes vasodilatadores endoteliales y de las especies reactivas de ox\u00edgeno y de nitr\u00f3geno en dicho efecto vasoconstrictor.  nuestros resultados indican que:  1,- en condiciones basales, t-booh induce vasoconstricci\u00f3n dependiente de la concentraci\u00f3n en segmentos con y sin endotelio de aorta y caudal de ratas wkt y shr de 6, 18 y 24 meses. La arteria aorta muestra una mayor sensibilidad al estr\u00e9s oxidativo que la arteria caudal. Adem\u00e1s, esta vasoconstricci\u00f3n se potencia con la hipertensi\u00f3n y con la ausencia del endotelio en ambas cepas.  2,- el t-booh produce un efecto delet\u00e9reo en la maquinaria contr\u00e1ctil de estas a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Role of oxidative stress in the vascular dysfunction related to hypertension and aging<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Role of oxidative stress in the vascular dysfunction related to hypertension and aging <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Edith-clara Garc\u00eda Cohen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Rodr\u00edguez Mart\u00ednez M. Angeles<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Garc\u00eda Garc\u00eda <\/li>\n<li>Mar\u00eda  monica De la fuente del rey (vocal)<\/li>\n<li>mercedes Salaices s\u00e1nchez (vocal)<\/li>\n<li>maurice Wbo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Edith-clara Garc\u00eda Cohen Los radicales libres derivados del ox\u00edgeno y los derivados de peroxidaci\u00f3n lip\u00eddica juegan un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,9,2445,189,957,6530,483,156,1601],"tags":[2451,55206,4610,55208,5260,55207],"class_list":["post-17669","post","type-post","status-publish","format-standard","hentry","category-alcala","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacodinamia","category-farmacologia","category-farmacologia-experimental","category-mecanismos-de-accion-de-los-farmacos","category-patologia","category-patologia-cardiovascular","tag-antonio-garcia-garcia","tag-edith-clara-garcia-cohen","tag-maria-monica-de-la-fuente-del-rey","tag-maurice-wbo","tag-mercedes-salaices-sanchez","tag-rodriguez-Martinez-m-angeles"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17669"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17669\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}