{"id":17682,"date":"2018-03-09T09:05:51","date_gmt":"2018-03-09T09:05:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-leptina-sobre-el-epitelio-intestinal-inmunolocalizacion-del-receptor-or-rb-en-los-enterocitos\/"},"modified":"2018-03-09T09:05:51","modified_gmt":"2018-03-09T09:05:51","slug":"efectos-de-la-leptina-sobre-el-epitelio-intestinal-inmunolocalizacion-del-receptor-or-rb-en-los-enterocitos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efectos-de-la-leptina-sobre-el-epitelio-intestinal-inmunolocalizacion-del-receptor-or-rb-en-los-enterocitos\/","title":{"rendered":"Efectos de la leptina sobre el epitelio intestinal. inmunolocalizaci\u00f3n del receptor or-rb en los enterocitos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jaione Barrenetxe Huici <\/strong><\/h2>\n<p>El descubrimiento de la leptina en 1994 y la identificaci\u00f3n de sus receptores funcionales en m\u00faltiples tejidos perif\u00e9ricos, incluido el intestino, ha hecho que en los \u00faltimos a\u00f1os se considere que la leptina podr\u00eda tener numerosos efectos perif\u00e9ricos adem\u00e1s del papel en la regulaci\u00f3n del peso corporal y el gasto energ\u00e9tico.  estudios preliminares llevado a cabo en el departamento hab\u00eda demostrado mediante t\u00e9cnicas in vitro que la leptina inhibe el transporte intestinal de galactosa en rata. El presente trabajo contin\u00faa con esos estudios iniciales en intestino de rata, que se ampl\u00edan a otras especies como la especie humana y el rat\u00f3n.  en primer lugar se ha determinado, mediante t\u00e9cnicas in vitro, que la leptina tambi\u00e9n inhibe el transporte intestinal de galactosa en rat\u00f3n disminuyendo la afinidad del transporte por el az\u00facar sin modificar el transporte m\u00e1ximo. por otro lado se ha comprobado el efecto inhibidor de la hormona sobre la captaci\u00f3n de alfa-metilgluc\u00f3sido en c\u00e9lulas intestinales humanas, utilizando como modelo de estudio la l\u00ednea celular de adenocarcinoma de colon caco-2. en esta misma l\u00ednea celular tambi\u00e9n se ha observado la capacidad de la leptina para regular la actividad proliferativa de estas c\u00e9lulas epiteliales.  por otra parte, se ha demostrado el papel modulador de la hormona sobre la actividad de las enzimas intestinales sacarasa, maltasa y atpasa dependiente de na+\/k+ utilizando homogenado intestinal de mucosa de rata. Adem\u00e1s, se ha demostrado la implicaci\u00f3n de la prote\u00edna quinasa c como mediador de la leptina en la inhibici\u00f3n del transporte intestinal de galactosa en rata, mediante t\u00e9cnicas inv itro y bioqu\u00edmicas (western blot).  por \u00fatlimo, mediante t\u00e9cnicas inmunocitoqu\u00edmicas de microscop\u00eda \u00f3ptica y electr\u00f3nica, se ha identificado la presencia del receptor largo de la leptina, ob-rb, en los enterocitos de rata, rat\u00f3n y humano. Tambi\u00e9n se ha determinado la presencia de mrna<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la leptina sobre el epitelio intestinal. inmunolocalizaci\u00f3n del receptor or-rb en los enterocitos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la leptina sobre el epitelio intestinal. inmunolocalizaci\u00f3n del receptor or-rb en los enterocitos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jaione Barrenetxe Huici <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Pilar Lostao Crespo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Villaro gumpert Ana cristina <\/li>\n<li>joana Mar\u00eda Planas rossell\u00f3 (vocal)<\/li>\n<li>Mar\u00eda \u00e1ngela Burrell bustos (vocal)<\/li>\n<li>carmen Mar\u00eda Vazquez cueto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jaione Barrenetxe Huici El descubrimiento de la leptina en 1994 y la identificaci\u00f3n de sus receptores funcionales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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