{"id":17690,"date":"2018-03-09T09:05:52","date_gmt":"2018-03-09T09:05:52","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-de-accion-carda%c2%adacos-implicados-en-el-efecto-del-neuropeptido-y\/"},"modified":"2018-03-09T09:05:52","modified_gmt":"2018-03-09T09:05:52","slug":"mecanismos-de-accion-carda%c2%adacos-implicados-en-el-efecto-del-neuropeptido-y","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-de-accion-carda%c2%adacos-implicados-en-el-efecto-del-neuropeptido-y\/","title":{"rendered":"Mecanismos de acci\u00f3n card\u00edacos implicados en el efecto del neuropeptido y"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Heredia Ochoa M. Puy <\/strong><\/h2>\n<p>Desde el descubrimiento del neurop\u00e9ptido y (npy), en 1982 (tatemoto y cols., 1982), muchos investigadores han estudiado sus efectos en el sistema cardiovascular. Sin embargo, a pesar del elevado n\u00famero de estudios cient\u00edficos relacionados con las acciones del p\u00e9ptido, en el coraz\u00f3n, no hab\u00eda ning\u00fan estudio concluyente sobre la contractilidad card\u00edaca, ni tampoco sobre los mecanismos de acci\u00f3n intracelulares. Gracias a la disposici\u00f3n de t\u00e9cnicas tales como la electrofisiolog\u00eda y la fluorescencia, se llev\u00f3 a cabo un estudio detallado de los efectos del npy en el coraz\u00f3n. La t\u00e9cnica de fluorescencia en microscop\u00eda confocal permiti\u00f3 el estudio simult\u00e1neo de los movimientos de ca2+ libre citoplasm\u00e1tico ((ca2+)i) y de la contrataci\u00f3n celular. Por su parte, la t\u00e9cnica electrofisiol\u00f3gica de patch-clamp nos permiti\u00f3 el estudio de la modulaci\u00f3n por npy de las principales corrientes i\u00f3nicas de membrana.  los primeros objetivos se plantearon con el fin de clarificar la controversia existente en cuanto al efecto inotr\u00f3pico del npy y al mecanismo de transducci\u00f3n implicado en dicho efecto, en miocitos ventriculares de rata. En este sentido, los resultados mostraron que el npy induc\u00eda un aumento de la amplitud del transiente global de (ca2+)i y la aceleraci\u00f3n de su cin\u00e9tica de relajaci\u00f3n. dichas variaciones de las caracter\u00edsticas del transiente, podr\u00edan explicarse por un aumento en la carga del ret\u00edculo sarcopl\u00e1smico (rs), un aumento de la amplitud de sus constituyentes elementales (los sparks de ca2+), o bien por el incremento de frecuencia de los mismos. Todo ello, en conjunto, influy\u00f3 dr\u00e1sticamente en el aumento de la contracci\u00f3n del miocito, observando durante la aplicaci\u00f3n de npy.  por su parte, tambi\u00e9n se puso de manifiesto, que el efecto del npy estaba mediado por la modulaci\u00f3n de la se\u00f1alizaci\u00f3n de ca2+, a trav\u00e9s de su uni\u00f3n al receptor y1. A su vez, en la cascada intracelular podr\u00eda verser implicada<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos de acci\u00f3n card\u00edacos implicados en el efecto del neuropeptido y<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos de acci\u00f3n card\u00edacos implicados en el efecto del neuropeptido y <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Heredia Ochoa M. Puy <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Delgado Canencia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fern\u00e1ndez <\/li>\n<li> Ram\u00f3n gim\u00e9nez Jos\u00e9 ram\u00f3n (vocal)<\/li>\n<li>rosal\u00eda Carr\u00f3n de la calle (vocal)<\/li>\n<li> Fern\u00e1ndez tome m. paz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Heredia Ochoa M. Puy Desde el descubrimiento del neurop\u00e9ptido y (npy), en 1982 (tatemoto y cols., 1982), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,2444],"tags":[23437,55252,55251,898,23440,39332],"class_list":["post-17690","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacos-naturales","tag-carmen-delgado-canencia","tag-fernandez-tome-m-paz","tag-heredia-ochoa-m-puy","tag-pedro-lorenzo-fernandez","tag-ramon-gimenez-jose-ramon","tag-rosalia-carron-de-la-calle"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17690","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17690"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17690\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17690"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17690"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17690"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}