{"id":17729,"date":"2018-03-09T09:05:55","date_gmt":"2018-03-09T09:05:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-mecanismos-de-resistencia-a-metronidazol-en-la-infeccion-por-helicobacter-pylori\/"},"modified":"2018-03-09T09:05:55","modified_gmt":"2018-03-09T09:05:55","slug":"estudio-de-los-mecanismos-de-resistencia-a-metronidazol-en-la-infeccion-por-helicobacter-pylori","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-los-mecanismos-de-resistencia-a-metronidazol-en-la-infeccion-por-helicobacter-pylori\/","title":{"rendered":"Estudio de los mecanismos de resistencia a metronidazol en la infecci\u00f3n por helicobacter pylori"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Obra Sanz Pilar De La <\/strong><\/h2>\n<p>Helicobacter pylori es un bacilo gram negativo, infecta aproximadamente a la mitad de la poblaci\u00f3n mundial, causando gastritis, \u00falcera g\u00e1strica y tambi\u00e9n se asocia con adenocarcinoma g\u00e1strico y linfoma tipo malt. El tratamiento de la infecci\u00f3n requiere varios f\u00e1rmacos, entre ellos antimicrobianos como el metronidazol. La preValencia de la resistencia a metronidazol varia entre el 11 y el 70% dependiendo de la poblaci\u00f3n estudiada y la aparici\u00f3n de ella conlleva una p\u00e9rdida significativa de la eficacia del tratamiento erradicador.  el objetivo de esta tesis fue estudiar la preValencia de la resistencia a metronidazol, nitrofuranto\u00edna y furazolidona durante un periodo de cuatro a\u00f1os y determinar las caracter\u00edsticas de la poblaci\u00f3n que puden ser factores de riesgo para la resistencia antibi\u00f3tica. As\u00ed como, el estudio de distintos aspectos de la resistencia a metronizadol (tasa de mutaci\u00f3n espont\u00e1nea, implicaciones del gen rdxa y frxa, preValencia de infecciones mixtas con cepas sensibles y resistencia a los 5-nitrofuranos, la utilidad cl\u00ednica de la prote\u00edna rdxa en la detecci\u00f3n de resistencia a metronidazol) en aislamientos cl\u00ednicos de h. Pylori obtenidos en nuestro \u00e1mbito.  para ello se utilizaron las t\u00e9cnicas microbiol\u00f3gicas cl\u00e1sicas de cultivo y determinaci\u00f3n de la sensibilidad, adem\u00e1s de t\u00e9cnicas de inmunotransferencia y de biolog\u00eda molecular basadas en la pcr.  encontramos que en nuestro \u00e1mbito la resistencia a metronidazol fue de 23,77% de 0,6% para nitrofuranto\u00edna y del 1,8% para furazolidona. El aislamiento simult\u00e1neo de cepas sensibles y resistentes en el mismo paciente se debi\u00f3 a la misma cepa con heterorresistencia a metronidazol. Encontramos una clara implicaci\u00f3n de gen rdxa en la resistencia al metronidazol. La nitrofuranto\u00edna y furazolidona tuvieron tasas de mutaci\u00f3n espont\u00e1neas muy inferiores al metronidazol. Existe una alta correlaci\u00f3n entre la producci\u00f3n de la prote\u00edna rdxa, detectad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los mecanismos de resistencia a metronidazol en la infecci\u00f3n por helicobacter pylori<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los mecanismos de resistencia a metronidazol en la infecci\u00f3n por helicobacter pylori <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Obra Sanz Pilar De La <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>brea Calvo L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Prieto prieto <\/li>\n<li>teresa Alarc\u00f3n cavero (vocal)<\/li>\n<li> Mart\u00ednez g\u00f3mez m. josefa (vocal)<\/li>\n<li> Sanz moreno Juan  Carlos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Obra Sanz Pilar De La Helicobacter pylori es un bacilo gram negativo, infecta aproximadamente a la mitad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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