{"id":17757,"date":"2018-03-09T09:05:59","date_gmt":"2018-03-09T09:05:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-apoptosis-inducida-por-la-mdma-en-celulas-hepaticas-de-rata\/"},"modified":"2018-03-09T09:05:59","modified_gmt":"2018-03-09T09:05:59","slug":"estudio-de-la-apoptosis-inducida-por-la-mdma-en-celulas-hepaticas-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-la-apoptosis-inducida-por-la-mdma-en-celulas-hepaticas-de-rata\/","title":{"rendered":"Estudio de la apoptosis inducida por la mdma. en c\u00e9lulas hep\u00e1ticas de rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Montiel Duarte <\/strong><\/h2>\n<p>La mdma (3,1-metilendioximetanfetamina) o \u00ab\u00e9xtasis\u00bb es un derivado de la anfetamina cuyo consumo produce hepatotoxicidad en humanos.  en este estudio se demuestra que en hepatocitos primarios de rata y en una l\u00ednea celular de c\u00e9lulas estelares hep\u00e1ticas (ceh) de rata, la administraci\u00f3n de mdma produce apoptosis. Esta apoptosis cursa con condensaci\u00f3n nuclear, acumulaci\u00f3n de fragmentos oligonucleosomales en el citoplasma, disminuci\u00f3n de los niveles de la prote\u00edna bcl-xl, salida de citocromo c desdela mitocondria y activaci\u00f3n de la caspasa-3. Adem\u00e1s, en el caso de las ceh y no en el de los hepatocitos, la administraci\u00f3n de la mdma produce la proteolisis de la prote\u00edna poliadp-ribosa polimerasa.  el posible papel del estr\u00e9s oxidativo en la acci\u00f3n apopt\u00f3tica de la mdma se estudi\u00f3 en las ceh. La mdma provoc\u00f3 estr\u00e9s oxidativo en estas c\u00e9lulas, con un aumento del agua oxigenada y un descenso de los niveles de gsh intracelulares. sin embargo, el estr\u00e9s oxidativo no es un mediador de la acci\u00f3n apopt\u00f3tica, ya que el pretratamiento con antioxidantes no inhibi\u00f3 la muerte celular.  la mdma indujo la activaci\u00f3n del factor nfkb, pero la inhibici\u00f3n de \u00e9ste aument\u00f3 la apoptosis indicando que su acci\u00f3n es protectora.  la inhibici\u00f3n del citocromo p450 previno la acci\u00f3n proapopt\u00f3tica de la mdma, indicando que un derivado de la droga es responsable de su efecto apopt\u00f3tico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la apoptosis inducida por la mdma. en c\u00e9lulas hep\u00e1ticas de rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la apoptosis inducida por la mdma. en c\u00e9lulas hep\u00e1ticas de rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Montiel Duarte <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Jose Iraburu Elizalde<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esteban Santiago calvo <\/li>\n<li>Jos\u00e9 vicente Castells ripoll (vocal)<\/li>\n<li>edurne Cenarruzabeitia sagarminaga (vocal)<\/li>\n<li>Elena Alberdi alfonso (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Montiel Duarte La mdma (3,1-metilendioximetanfetamina) o \u00ab\u00e9xtasis\u00bb es un derivado de la anfetamina cuyo consumo produce [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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