{"id":17771,"date":"2018-03-09T09:06:00","date_gmt":"2018-03-09T09:06:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-tratamiento-con-gh-sobre-el-sistema-igf-i-igfbps-en-la-artritis-experimental\/"},"modified":"2018-03-09T09:06:00","modified_gmt":"2018-03-09T09:06:00","slug":"efecto-del-tratamiento-con-gh-sobre-el-sistema-igf-i-igfbps-en-la-artritis-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-del-tratamiento-con-gh-sobre-el-sistema-igf-i-igfbps-en-la-artritis-experimental\/","title":{"rendered":"Efecto del tratamiento con gh sobre el sistema igf-i\/igfbps en la artritis experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Inmaculada Ib\u00e1\u00f1ez De Caceres <\/strong><\/h2>\n<p>La artritis experimental inducida en ratas tras la administraci\u00f3n de adyuvante completo de freund, se utiliza como modelo animal para el estudio de la inflamaci\u00f3n cr\u00f3nica y de la artritis reumatoide humana. Este modelo cursa con la inflamaci\u00f3n de las articulaciones y p\u00e9rdida de peso corporal. esta disminuci\u00f3n parece ser debida, en parte, a alteraciones en el sistema endocrino, ya que se han descrito una disminuci\u00f3n de la s\u00edntesis y secreci\u00f3n hipofisaria de gh, un descenso en los niveles s\u00e9ricos del igf-i, y un aumento de los niveles de sus prote\u00ednas circulantes (igfbps) en el suero. Por otra parte, la artritis experimental tambi\u00e9n produce alteraciones en la funci\u00f3n renal. En esta enfermedad se ha descrito un aumento en los niveles plasm\u00e1ticos de creatinina junto con un descenso en su aclaraci\u00f3n renal, aumento de la diuresis y alteraciones histopatol\u00f3gicas en el ri\u00f1\u00f3n.  por todo ello, los objetivos de esta tesis fueron:  1,- analizar si la artritis experimental induce un estado de resistencia a la gh.  2,- dilucidar si el aumento de la igfbp-3 s\u00e9rica que se observa en la artritis experimental, se debe a un aumento de su s\u00edntesis hep\u00e1tica o a un aumento de si vida media en plasma.  3,- analizar si la artritis experimental induce alteraciones en el sistema igf-i renal, y si la administraci\u00f3n de gh es capaz de revertir estos efectos.  respecto al primer objetivo, no observamos resistencia hep\u00e1tica a la gh en la artritis experimental, puesto que no se altera la expresi\u00f3n hep\u00e1tica del gen del receptor de la gh y adem\u00e1s, la administraci\u00f3n de gh, aumenta tanto los niveles del igf-i como el peso corporal. El aumento de la igfbp-3 s\u00e9rica en la artritis experimental, no parece deberse a un aumento de su s\u00edntesis hep\u00e1tica, sino a un aumento de su vida media en el plasma, ya que la artritis disminuye su proteolisis en el plasma. En el ri\u00f1\u00f3n, observamos que la artritis experimental induce un aumento en la concentraci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del tratamiento con gh sobre el sistema igf-i\/igfbps en la artritis experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del tratamiento con gh sobre el sistema igf-i\/igfbps en la artritis experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Inmaculada Ib\u00e1\u00f1ez De Caceres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>calder\u00f3n Barreda L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li> Mart\u00edn velasco Ana isabel (vocal)<\/li>\n<li>enrique Aguilar benitez de lugo (vocal)<\/li>\n<li>meritxel L\u00f3pez gallardo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Inmaculada Ib\u00e1\u00f1ez De Caceres La artritis experimental inducida en ratas tras la administraci\u00f3n de adyuvante completo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,675,817,226],"tags":[55462,2380,55461,4610,55463,23729],"class_list":["post-17771","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-fisiologia-animal","category-fisiologia-humana","category-zoologia","tag-calderon-barreda-lopez","tag-enrique-aguilar-benitez-de-lugo","tag-m-inmaculada-ibanez-de-caceres","tag-maria-monica-de-la-fuente-del-rey","tag-martin-velasco-ana-isabel","tag-meritxel-lopez-gallardo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17771"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17771\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17771"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17771"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}