{"id":17782,"date":"2018-03-09T09:06:01","date_gmt":"2018-03-09T09:06:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-metamizol-sobre-la-expresion-de-las-ciclooxigenasas-en-mucosa-gastrica-de-rata-sometida-a-ulcerogenesis\/"},"modified":"2018-03-09T09:06:01","modified_gmt":"2018-03-09T09:06:01","slug":"efectos-de-metamizol-sobre-la-expresion-de-las-ciclooxigenasas-en-mucosa-gastrica-de-rata-sometida-a-ulcerogenesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-metamizol-sobre-la-expresion-de-las-ciclooxigenasas-en-mucosa-gastrica-de-rata-sometida-a-ulcerogenesis\/","title":{"rendered":"Efectos de metamizol sobre la expresi\u00f3n de las ciclooxigenasas en mucosa g\u00e1strica de rata sometida a ulcerogenesis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bettiana Berenguer Froehner <\/strong><\/h2>\n<p>En este trabajo se ha comparado el efecto de tres antiinflamatorios no esteroides de perfiles farmacol\u00f3gicos diferentes (metomizol, celecoxil y piroxicam), sobre varios modelos de \u00falcera aguda y \u00falcera cr\u00f3nica en ratas. En los modelos agudos hemos comprobado, que si bien celecoxil no provoca apenas da\u00f1o sobre una mucosa g\u00e1strica sana, exacerba las lesiones g\u00e1stricas preexistentes. Piroxicam caus\u00f3 da\u00f1o en el modelo de administraci\u00f3n \u00fanica y tambi\u00e9n empeor\u00f3 el estado de la mucosa previamente inflamada. Por el contrario metemizol reflej\u00f3 un comportamiento muy benigno en todos los modelos agudos de las dosis mayores ensayadas.  en el modelo de \u00falcera cr\u00f3nica, se observ\u00f3 un retraso muy importante en la curaci\u00f3n de la lesi\u00f3n g\u00e1strica cuando se administr\u00f3 a los animales durante 15 d\u00edas celecoxil 2 veces al d\u00eda. Este retraso se podr\u00eda explicar con la inhibici\u00f3n de la expresi\u00f3n de la cicloxigenasa 2 observada.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de metamizol sobre la expresi\u00f3n de las ciclooxigenasas en mucosa g\u00e1strica de rata sometida a ulcerogenesis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de metamizol sobre la expresi\u00f3n de las ciclooxigenasas en mucosa g\u00e1strica de rata sometida a ulcerogenesis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bettiana Berenguer Froehner <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mart\u00edn Calero M. Jose<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: concepcion Navarro mol <\/li>\n<li>Antonio Caballero plasencia (vocal)<\/li>\n<li>Javier Mi\u00f1ano s\u00e1nchez (vocal)<\/li>\n<li>inmaculada Bellido est\u00e9vez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bettiana Berenguer Froehner En este trabajo se ha comparado el efecto de tres antiinflamatorios no esteroides de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,35,9,2445,957,5531,817,3178,17,10715],"tags":[35314,55487,55489,38469,55490,55488],"class_list":["post-17782","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-fisiologia-gastrointestinal","category-fisiologia-humana","category-proteinas","category-quimica","category-sevilla","tag-antonio-caballero-plasencia","tag-bettiana-berenguer-froehner","tag-concepcion-navarro-mol","tag-inmaculada-bellido-estevez","tag-javier-minano-sanchez","tag-martin-calero-m-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17782"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17782\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}