{"id":17809,"date":"2018-03-09T09:06:03","date_gmt":"2018-03-09T09:06:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunogenetica-de-la-esclerosis-multiple-estudios-de-asociacion-y-ligamiento-en-la-poblacion-espanola\/"},"modified":"2018-03-09T09:06:03","modified_gmt":"2018-03-09T09:06:03","slug":"inmunogenetica-de-la-esclerosis-multiple-estudios-de-asociacion-y-ligamiento-en-la-poblacion-espanola","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/inmunogenetica-de-la-esclerosis-multiple-estudios-de-asociacion-y-ligamiento-en-la-poblacion-espanola\/","title":{"rendered":"Inmunogen\u00e9tica de la esclerosis m\u00faltiple; estudios de asociaci\u00f3n y ligamiento en la poblaci\u00f3n espa\u00f1ola"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Rubio Jare\u00f1o <\/strong><\/h2>\n<p>La esclerosis m\u00faltiple (em) es la enfermedad neurol\u00f3gica m\u00e1s frecuente en los adultos j\u00f3venes del norte de europa y am\u00e9rica. Se trata de una enfermedad cr\u00f3nica del sistema nervioso central (snc) que se caracteriza por la formaci\u00f3n de lesiones en forma de placas en la mielina de los nervios.  la epidemiolog\u00eda ha aportado una informaci\u00f3n considerable sobre los factores de susceptibilidad a la em. La descripci\u00f3n de gradientes geogr\u00e1ficos de preValencia y los estudios de migraci\u00f3n apoyan la existencia de factores ambientales, presumiblemente infecciosos. Sin embargo, la distribuci\u00f3n irregular de la preValencia seg\u00fan el fondo racial, y sobre todo, la mayor frecuencia de la enfermedad entre familiares de pacientes y particularmente entre gemelos monozigotos son s\u00f3lidos argumentos a favor de una susceptibilidad gen\u00e9tica, que seg\u00fan toda evidencia, incluida la disponibilidad de los modelos experimentales de em, implica la interacci\u00f3n de varios genes. A lo largo de los \u00faltimos decenios se han valorado en estudios de asociaci\u00f3n y de ligamiento numerosos genes candidaros seg\u00fan la idea de una patogenia mediada inmunol\u00f3gicamente contra ant\u00edgenos de la mielina del snc, y recientemente se han efectuado estudios de ligamiento rastreando todo el genoma con marcadores an\u00f3nimos. Los resultados disponibles, con discrepancias entre estudios, subrayan el papel de la regi\u00f3n del complejo mayor de histocompatibilidad (mhc), localizado en el brazo corto del cromosoma 6, como el determinante gen\u00e9tico para la em.  los objetivos planteados en esta tesis fueron:  1,- encontrar, tanto dentro del mhc como fuera de \u00e9l, genes asociados primariamente a la susceptibilidad a padecer em. Este estudio se realizar\u00e1 mediante un an\u00e1lisis caso-control que podr\u00e1 determinar loci adicionales de riesgo aparte del ya conocido alelo de susceptibilidad de clase ii, hla-drb1*1501.  2,- evaluar si las asociaciones positivas o negativas encontradas se deben<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunogen\u00e9tica de la esclerosis m\u00faltiple; estudios de asociaci\u00f3n y ligamiento en la poblaci\u00f3n espa\u00f1ola<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunogen\u00e9tica de la esclerosis m\u00faltiple; estudios de asociaci\u00f3n y ligamiento en la poblaci\u00f3n espa\u00f1ola <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Rubio Jare\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> G\u00f3mez De La Concha Emilio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  monica De la fuente del rey <\/li>\n<li>Jos\u00e9 Carlos \u00e1lvarez cerme\u00f1o (vocal)<\/li>\n<li>pilar Palomino diaz (vocal)<\/li>\n<li> Urcela y Garc\u00eda Elena (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Rubio Jare\u00f1o La esclerosis m\u00faltiple (em) es la enfermedad neurol\u00f3gica m\u00e1s frecuente en los adultos j\u00f3venes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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