{"id":17842,"date":"2018-03-09T09:06:06","date_gmt":"2018-03-09T09:06:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-endotoxinas-lipopolisacaridos-de-las-bacterias-del-genero-yersinia-en-la-patogenicidad-induccion-de-citocinas-interaccion-con-policationes-y-efecto-citotoxico\/"},"modified":"2018-03-09T09:06:06","modified_gmt":"2018-03-09T09:06:06","slug":"papel-de-la-endotoxinas-lipopolisacaridos-de-las-bacterias-del-genero-yersinia-en-la-patogenicidad-induccion-de-citocinas-interaccion-con-policationes-y-efecto-citotoxico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-la-endotoxinas-lipopolisacaridos-de-las-bacterias-del-genero-yersinia-en-la-patogenicidad-induccion-de-citocinas-interaccion-con-policationes-y-efecto-citotoxico\/","title":{"rendered":"Papel de la endotoxinas (lipopolisac\u00e1ridos) de las bacterias del g\u00e9nero yersinia en la patogenicidad: inducci\u00f3n de citocinas, interacci\u00f3n con policationes y efecto citot\u00f3xico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Arraiza Saldise M. Dolores <\/strong><\/h2>\n<p>El g\u00e9nero yersinia constituye un modelo adecuado para estudiar ciertos aspectos de la relaci\u00f3n entre patogenicidad y estructura de la membrana externa, dada la gradaci\u00f3n de virulencia que existe entre deterinadas especies y biotipos del g\u00e9nero y la variaci\u00f3n de algunas propiedades en funci\u00f3n de las condiciones de cultivo. Estas diferencias se manifiestan en la resistencia a los policationes bactericidas y la permeabilidad a los agentes hidrof\u00f3bicos. dado que las propiedades de la membrana externa dependen estrechamente de la estructura del lps, se formula la hip\u00f3tesis de que el lps de las especies pat\u00f3genas de yersinia funciona como un factor de virulencia por tener el patr\u00f3n molecular alterado.  en el presente trabajo se confirma la alteraci\u00f3n en el patr\u00f3n molecular del lps en las especies pat\u00f3geneas de yersinia, y se muestra la existencia de una relaci\u00f3n entre esta alteraci\u00f3n y un reconocimiento defectuoso por parte del sistema de defensa innato, como muestra su baja activaci\u00f3n del complemento y su baja endotoxicidad.  adem\u00e1s, se demuestra la relaci\u00f3n entre fluidez de las cadenas acilo y permeabilidad a los agentes hidrof\u00f3bicos, y entre acilaci\u00f3n del l\u00edpido a y fluidez.  tambi\u00e9n, se muestra c\u00f3mo la menor virulencia de los mutantes de y.Enterocolitica 0:3 deficientes en el n\u00facleo externo del lps se explica no s\u00f3lo por su mayor sensibilidad a los policationes, sino tambi\u00e9n por su mayor capacidad de activar el complemento cuanto la bacteria crece a la temperatura de sus hu\u00e9spedes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la endotoxinas (lipopolisac\u00e1ridos) de las bacterias del g\u00e9nero yersinia en la patogenicidad: inducci\u00f3n de citocinas, interacci\u00f3n con policationes y efecto citot\u00f3xico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la endotoxinas (lipopolisac\u00e1ridos) de las bacterias del g\u00e9nero yersinia en la patogenicidad: inducci\u00f3n de citocinas, interacci\u00f3n con policationes y efecto citot\u00f3xico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Arraiza Saldise M. Dolores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Moriyon Uria<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n Luis D\u00edaz Garc\u00eda <\/li>\n<li>Jos\u00e9 Antonio Bengoechea alonso (vocal)<\/li>\n<li>alfonso Ruiz-bravo l\u00f3pez (vocal)<\/li>\n<li>maite Iriarte cilveti (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arraiza Saldise M. Dolores El g\u00e9nero yersinia constituye un modelo adecuado para estudiar ciertos aspectos de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,41163,597,17749,156],"tags":[21739,55646,10696,55647,55648,10691],"class_list":["post-17842","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-endotoxinas","category-microbiologia-clinica","category-navarra","category-patologia","tag-alfonso-ruiz-bravo-lopez","tag-arraiza-saldise-m-dolores","tag-ignacio-moriyon-uria","tag-jose-antonio-bengoechea-alonso","tag-maite-iriarte-cilveti","tag-ramon-luis-diaz-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=17842"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/17842\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=17842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=17842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=17842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}