{"id":17854,"date":"2018-03-09T09:06:07","date_gmt":"2018-03-09T09:06:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/investigacion-y-desarrollo-de-un-nuevo-medicamento-generico-comprimidos-de-alprazolam-1-mg\/"},"modified":"2018-03-09T09:06:07","modified_gmt":"2018-03-09T09:06:07","slug":"investigacion-y-desarrollo-de-un-nuevo-medicamento-generico-comprimidos-de-alprazolam-1-mg","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/investigacion-y-desarrollo-de-un-nuevo-medicamento-generico-comprimidos-de-alprazolam-1-mg\/","title":{"rendered":"Investigaci\u00f3n y desarrollo de un nuevo medicamento gen\u00e9rico: comprimidos de alprazolam 1 mg"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Perez Lozano <\/strong><\/h2>\n<p>El objetivo principal de este estudio consiste en la investigaci\u00f3n y desarrollo de la formulaci\u00f3n de un nuevo medicamento gen\u00e9rico, comprimidos de alprazolam 1 mg, siguiendo las especificaciones indicadas en la modificaci\u00f3n de la ley del medicamento y posteriores circulares del ministerio de sanidad y consumo, donde se establecen los requisitos t\u00e9cnico-sanitarios que deben cumplir estas especialidades farmac\u00e9uticas para garantizar su calidad, seguridad y eficiencia.  para ello se realiza una investigaci\u00f3n gal\u00e9nica con el objetivo de desarrollar un aut\u00e9ntico medicamento seguro, eficaz, estable y de calidad, investigaci\u00f3n gal\u00e9nica que comprende una parte tecnol\u00f3gica y una parte biofarmac\u00e9utica. para la consecuci\u00f3n de este objetivo se desarrollan los siguientes objetivos parciales: establecimiento de las caracter\u00edsticas tecnol\u00f3gicas y de biodisponibilidad del medicamento innovador o de referencia, investigaci\u00f3n de las caracter\u00edsticas f\u00edsico-qu\u00edmicas y tecnolog\u00edas de la materia prima, estudio de la formulaci\u00f3n donde se incluye la investigaci\u00f3n experimental de la compatibilidad de los excipientes estudiados con el principio activo y posterior estudio de la t\u00e9cnica de elaboraci\u00f3n, estudio de transposici\u00f3n de escala con la fabricaci\u00f3n de tres lotes a escala piloto, estudio comparativo de las cin\u00e9ticas de disoluci\u00f3n de la especialidad farmac\u00e9utica de referencia con los tres lotes fabricados a escala piloto, control del producto acabado, estudio de estabilidad seg\u00fan las gu\u00edas ich para dicho producto y por \u00faltimo el estudio de bioequiValencia.  tras el estudio realizado se concluye que la formulaci\u00f3n propuesta y la t\u00e9cnica de elaboraci\u00f3n mediante una comprensi\u00f3n previa granulaci\u00f3n por v\u00eda h\u00fameda acuosa, ha hecho posible obtener un nuevo medicamento gen\u00e9rico, seguro, estable (con un tiempo de caducidad de tres a\u00f1os), eficaz, de calidad y bioequivalente con respecto al medicamento de referencia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Investigaci\u00f3n y desarrollo de un nuevo medicamento gen\u00e9rico: comprimidos de alprazolam 1 mg<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Investigaci\u00f3n y desarrollo de un nuevo medicamento gen\u00e9rico: comprimidos de alprazolam 1 mg <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Perez Lozano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep Mar\u00eda Su\u00f1\u00e9 Negre<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Cemeli pons <\/li>\n<li> Montoro ronsano j. bruno (vocal)<\/li>\n<li>encarna Garc\u00eda montoya (vocal)<\/li>\n<li>miquel Tkka-catala genis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Perez Lozano El objetivo principal de este estudio consiste en la investigaci\u00f3n y desarrollo de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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