{"id":17881,"date":"2018-03-09T09:06:10","date_gmt":"2018-03-09T09:06:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-beneficioso-del-calcitriol-sobre-la-evolucion-de-la-diabetes-experimental-inducida-por-estreptozotocina-en-la-rata\/"},"modified":"2018-03-09T09:06:10","modified_gmt":"2018-03-09T09:06:10","slug":"efecto-beneficioso-del-calcitriol-sobre-la-evolucion-de-la-diabetes-experimental-inducida-por-estreptozotocina-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/efecto-beneficioso-del-calcitriol-sobre-la-evolucion-de-la-diabetes-experimental-inducida-por-estreptozotocina-en-la-rata\/","title":{"rendered":"Efecto beneficioso del calcitriol sobre la evoluci\u00f3n de la diabetes experimental inducida por estreptozotocina en la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Benito Vicente Gloria Elena <\/strong><\/h2>\n<p>El calcitriol, hormona asociada cl\u00e1sicamente con el metabolismo \u00f3seo, se ha sido relacionada recientemente con el p\u00e1ncreas endocrino: se ha descrito que el tratamiento con calcitriol, previo a la inducci\u00f3n de diabetes experimental, tiene un papel protector sobre el desarrollo de la enfermedad. Sin embargo, se desconoce si el calcitriol podr\u00eda tener un efecto positivo en el tratamiento de una diabetes ya establecida.  el primer objetivo de este trabajo fue la descripci\u00f3n de nuestro modelo de diabetes experimental, estudiando la micromorfolog\u00eda del p\u00e1ncreas en ratas tratadas con estreptozotocina (stz). As\u00ed observamos que la administraci\u00f3n de una \u00fanica dosis de 60 mg stz\/kg induce diabetes mellitus, provocando una dr\u00e1stica disminuci\u00f3n en el n\u00famero de islotes de langerhans y en el contenido de insulina pancre\u00e1tica. La evoluci\u00f3n a largo plazo de esta diabetes no es homog\u00e9nea, por lo que existen otros factores, a\u00fan no identificados, que intervienen en este modelo experimental.  en segundo lugar, comprobamos que el calcitriol disminuye las dosis de insulina ex\u00f3gena que precisan animales en los que se indujo diabetes con stz, y este efecto est\u00e1 asociado a un incremento en el contenido de insulina en el p\u00e1ncreas. Sin embargo, este hecho no ese acompa\u00f1a ni de incremento de insulina del n\u00famero de islotes ni de la presencia de insulina en zonas pancre\u00e1ticas extrainsulares. La administraci\u00f3n de calcitriol resulta, pues, beneficiosa para el control de la glucemia al disminuir las necesidades de insulina ex\u00f3gena y, por tanto, para la evoluci\u00f3n de la diabetes.  finalmente, nos propusimos dilucidar si el tratamiento con calcitriol ten\u00eda un efecto beneficioso sobre la osteoporosis y, en ese caso, a qu\u00e9 era debido dicho efecto. En este sentido, el efecto protector del calcitriol sobre la osteopenia diab\u00e9tica no es un efecto directo sobre el hueso, sino que es una consecuencia de la acci\u00f3n beneficiosa del calcitriol sobre la<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto beneficioso del calcitriol sobre la evoluci\u00f3n de la diabetes experimental inducida por estreptozotocina en la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto beneficioso del calcitriol sobre la evoluci\u00f3n de la diabetes experimental inducida por estreptozotocina en la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Benito Vicente Gloria Elena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Julian Calvo Andres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  L\u00f3pez rodr\u00edguez Mar\u00eda a. <\/li>\n<li> Miralles Garc\u00eda Jos\u00e9 Manuel (vocal)<\/li>\n<li>Jos\u00e9 Manuel Quesada gomez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Benito Vicente Gloria Elena El calcitriol, hormona asociada cl\u00e1sicamente con el metabolismo \u00f3seo, se ha sido relacionada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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