{"id":17886,"date":"2018-03-09T09:06:10","date_gmt":"2018-03-09T09:06:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/induccion-de-apoptosis-celular-en-pacientes-con-dano-cerebral-agudo-como-mecanismo-de-produccion-de-fenomenos-autoinmunes\/"},"modified":"2018-03-09T09:06:10","modified_gmt":"2018-03-09T09:06:10","slug":"induccion-de-apoptosis-celular-en-pacientes-con-dano-cerebral-agudo-como-mecanismo-de-produccion-de-fenomenos-autoinmunes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/induccion-de-apoptosis-celular-en-pacientes-con-dano-cerebral-agudo-como-mecanismo-de-produccion-de-fenomenos-autoinmunes\/","title":{"rendered":"Inducci\u00f3n de apoptosis celular en pacientes con da\u00f1o cerebral agudo como mecanismo de producci\u00f3n de fen\u00f3menos autoinmunes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Mi\u00f1ambres Garc\u00eda <\/strong><\/h2>\n<p>El suero procedente del drenaje venoso cerebral, de pacientes con traumatismo craneo-encef\u00e1lico o hemorragia intracraneal espontanea grave, presenta alg\u00fan factor soluble capaz de inducir apoptosis celular in vitro en celulas linfoides.  la tasa de apoptosis celular se relaciona con el pron\u00f3stico de los pacientes as\u00ed, como con todos los \u00edndices de gravedad estudiados al ingreso en la unidad de cuidados intensivos.  el factor soluble inductor de apoptosis es un opioide end\u00f3geno, generado tras la lesi\u00f3n cerebral, o ex\u00f3geno como el fentanilo.  la inducci\u00f3n de apoptosis se relaciona con un aumento de la expresi\u00f3n de bax (prote\u00edna intracelular pro-apopt\u00f3tica) y un descenso en la expresi\u00f3n de bcl-xl (prote\u00edna intracelular anti-apopt\u00f3tica).  las c\u00e9lulas jurkat apopt\u00f3ticas expresan autoant\u00edgenos que son reconocidos por autoanticuerpos de pacientes con enfermedades autoinmunes. Debido a la expresi\u00f3n de estos autoant\u00edgenos se induce, en los pacientes con da\u00f1o cerebral agudo, la producci\u00f3n de novo de autoanticuerpos meses despu\u00e9s de la agresi\u00f3n cerebral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inducci\u00f3n de apoptosis celular en pacientes con da\u00f1o cerebral agudo como mecanismo de producci\u00f3n de fen\u00f3menos autoinmunes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inducci\u00f3n de apoptosis celular en pacientes con da\u00f1o cerebral agudo como mecanismo de producci\u00f3n de fen\u00f3menos autoinmunes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Mi\u00f1ambres Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Rodr\u00edguez Valverde<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alvar net Castel <\/li>\n<li>Francisco Leyva cobi\u00e1n (vocal)<\/li>\n<li>\u00c1lvaro Castellanos ortega (vocal)<\/li>\n<li>emilia Civeira murillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Mi\u00f1ambres Garc\u00eda El suero procedente del drenaje venoso cerebral, de pacientes con traumatismo craneo-encef\u00e1lico o hemorragia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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