{"id":18010,"date":"2002-02-07T00:00:00","date_gmt":"2002-02-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-hemostaticos-relacionados-con-el-endotelio-homocistea%c2%adna-y-amonoacidos-neurotransmisores-en-los-pacientes-con-ictus-isquemico-agudo\/"},"modified":"2002-02-07T00:00:00","modified_gmt":"2002-02-07T00:00:00","slug":"factores-hemostaticos-relacionados-con-el-endotelio-homocistea%c2%adna-y-amonoacidos-neurotransmisores-en-los-pacientes-con-ictus-isquemico-agudo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/factores-hemostaticos-relacionados-con-el-endotelio-homocistea%c2%adna-y-amonoacidos-neurotransmisores-en-los-pacientes-con-ictus-isquemico-agudo\/","title":{"rendered":"Factores hemost\u00e1ticos relacionados con el endotelio, homociste\u00edna y amono\u00e1cidos neurotransmisores en los pacientes con ictus isqu\u00e9mico agudo"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00e9s Jim\u00e9nez M. Carmen <\/strong><\/h2>\n<p>Hip\u00f3tesis  1,- en los pacientes predispuestos al desarrollo de eventos isqu\u00e9micos hay disfunci\u00f3n endotelial, por tanto los par\u00e1metros de la hemostasia relacionados con el endotelio est\u00e1n alterados. En la isquemia cerebral aguda ocurren cambios locales que se reflejan en la circulaci\u00f3n general y que propician un aumento en sangre perif\u00e9rica de los factores hemost\u00e1ticos factor von willebrand, pai-1, tf y tfpi, todos ellos relacionados con la funci\u00f3n endotelial.  2,- el nivel elevado de homocisteinemia es un factor de riesgo vascular. adem\u00e1s se eleva tras los episodios isqu\u00e9micos agudos. Por tanto, en los pacientes con ictus, la elevaci\u00f3n de la homocisteinemia puede interpretarse como marcador de riesgo vascular causal y como una consecuencia del propio evento isqu\u00e9mico agudo.  3,- los niveles de los amino\u00e1cidos neurotransmisores glutamato, aspartato y glicina se elevan en el ictus isqu\u00e9mico, de forma proporcional a la extensi\u00f3n anat\u00f3mica y a la gravedad cl\u00ednica del proceso. Dado que los amino\u00e1cidos est\u00e1n presentes en todas las c\u00e9lulas es posible que los niveles s\u00e9ricos se encuentren tambi\u00e9n alterados en otras enfermedades distintas al ictus.  objetivos  1,- evaluar el comportamiento de los factores que intervienen en la hemostasia, y son, a la vez, marcadores de disfunci\u00f3n endotelial (factor von willebrand, pai-1, tf y tfpi) en los pacientes con ictus isqu\u00e9mico en el momento agudo y la evoluci\u00f3n posterior.  2,- estudiar el nivel plasm\u00e1tico de homociste\u00edna en la fase aguda del ictus y en la evoluci\u00f3n.  3,- analizar si los niveles s\u00e9ricos de los amino\u00e1cidos neurotransmisores glutamato, aspartato y glicina son marcadores exclusivos de ictus isqu\u00e9mico.  m\u00e9todo  se seleccionaron los pacientes que acudieron a urgencias con focalidad neurol\u00f3gica de menos de 24 horas de evoluci\u00f3n cuyo diagn\u00f3stico fue ictus isqu\u00e9mico. Se recogieron datos epidemiol\u00f3gicos y cl\u00ednicos y se realizaron determinaciones anal<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores hemost\u00e1ticos relacionados con el endotelio, homociste\u00edna y amono\u00e1cidos neurotransmisores en los pacientes con ictus isqu\u00e9mico agudo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores hemost\u00e1ticos relacionados con el endotelio, homociste\u00edna y amono\u00e1cidos neurotransmisores en los pacientes con ictus isqu\u00e9mico agudo <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00e9s Jim\u00e9nez M. Carmen <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jos\u00e9 V\u00e1zquez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Arnalich fern\u00e1ndez <\/li>\n<li>Luis Manzano espinosa (vocal)<\/li>\n<li> Barbado hern\u00e1ndez Francisco Javier (vocal)<\/li>\n<li>aurora Fern\u00e1ndez pavor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00e9s Jim\u00e9nez M. Carmen Hip\u00f3tesis 1,- en los pacientes predispuestos al desarrollo de eventos isqu\u00e9micos hay disfunci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,139,1880],"tags":[56097,56096,824,56095,4860,31857],"class_list":["post-18010","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-medicina-interna","category-neurologia","tag-aurora-fernandez-pavor","tag-barbado-hernandez-francisco-javier","tag-francisco-arnalich-fernandez","tag-garces-jimenez-m-carmen","tag-juan-jose-vazquez-rodriguez","tag-luis-manzano-espinosa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18010"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18010\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}