{"id":18033,"date":"2002-03-07T00:00:00","date_gmt":"2002-03-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estres-oxidativo-en-ciruga%c2%ada-cardiaca-de-sustitucion-y-valvular-con-isquemia-relacion-con-la-funcion-cardiovascular-postoperatoria\/"},"modified":"2002-03-07T00:00:00","modified_gmt":"2002-03-07T00:00:00","slug":"estres-oxidativo-en-ciruga%c2%ada-cardiaca-de-sustitucion-y-valvular-con-isquemia-relacion-con-la-funcion-cardiovascular-postoperatoria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estres-oxidativo-en-ciruga%c2%ada-cardiaca-de-sustitucion-y-valvular-con-isquemia-relacion-con-la-funcion-cardiovascular-postoperatoria\/","title":{"rendered":"Estr\u00e9s oxidativo en cirugia cardiaca de sustituci\u00f3n y valvular con isquemia. relaci\u00f3n con la funci\u00f3n cardiovascular postoperatoria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruben Jara Rubio <\/strong><\/h2>\n<p>La cirug\u00eda valvular cardiaca con clampaje a\u00f3rtico supone someter el coraz\u00f3n y los pulmores a un proceso de isquemia y reperfusi\u00f3n (i\/r). La isquemia-reperfusi\u00f3n se ha relacionado con la formaci\u00f3n de especies reactivas de ox\u00edgeno (ero); dichas especies reactivas producen da\u00f1o celular, al actuar sobre hidratos de carbono, proteinas, \u00e1cidos nucleicos y l\u00edpidos. La acci\u00f3n de ero es uno de los procesos fundamentales del da\u00f1o oxidativo, y se puden cuantificar midiendo los lipoper\u00f3xidos. Adem\u00e1s, se produce consumo de antioxidantes, cuantificable midiendo el estado antioxidante total del plasma. Asimismo, la i\/r puede da\u00f1ar el endotelio y producir un descenso en la generaci\u00f3n de \u00f3xido n\u00edtrico, o por el contrario la respuesta inflamatoria puede activar la oxido n\u00edtrico sintasa inducible y producir aumento importante en la concentraci\u00f3n de metabolitos de \u00f3xido n\u00edtrico. Nos planteamos en esta tesis doctoral comprobar si existe desequilibrio sobre la evoluci\u00f3n hemodin\u00e1mica y del resto de \u00f3rganos en el curso postoperatorio.  estudiamos 36 pacientes adultos con valvulopat\u00eda aortica, en situaci\u00f3n cl\u00ednica estable, sometidos a sustituci\u00f3n valvular por el servicio de cirug\u00eda cardiovascular y vigilados en el curso postoperatorio en la unidad de cuidados intensivos del hospital universitario virgen de la arrixaca de murcia. se excluyeron los pacientes con endocarditis.  hemos determinado el estado antioxidante total del plasma (m\u00e9todo abts), los lipoper\u00f3xidos malonilaldehido e hidroxialquenos mediante el kit byoxitech y los productos finales de \u00f3xido n\u00edtrico (nitritos\/nitratos) mediante la t\u00e9cnica de griess, en 8 momentos durante el proceso quir\u00fargico (inducci\u00f3n anest\u00e9sica, inicio de circulaci\u00f3n extracorp\u00f3rea, ingreso en la unidad de cuidados intensivos, 24 horas de evoluci\u00f3n postoperatoria y 48 horas de evoluci\u00f3n). Los par\u00e1metros hemodin\u00e1micos (ta, indice cardiaco, indice de resistencias vasculares sist\u00e9micas, pr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estr\u00e9s oxidativo en cirugia cardiaca de sustituci\u00f3n y valvular con isquemia. relaci\u00f3n con la funci\u00f3n cardiovascular postoperatoria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estr\u00e9s oxidativo en cirugia cardiaca de sustituci\u00f3n y valvular con isquemia. relaci\u00f3n con la funci\u00f3n cardiovascular postoperatoria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruben Jara Rubio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Carbonell Meseguer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: tom\u00e1s Quesada p\u00e9rez <\/li>\n<li>Juan Caturla such (vocal)<\/li>\n<li>gines Torres Martinez (vocal)<\/li>\n<li>ram\u00f3n Arcas meca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruben Jara Rubio La cirug\u00eda valvular cardiaca con clampaje a\u00f3rtico supone someter el coraz\u00f3n y los pulmores [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[932,9,141,2189,139,8235],"tags":[56157,31123,26844,56158,56156,24894],"class_list":["post-18033","post","type-post","status-publish","format-standard","hentry","category-cardiologia","category-ciencias-medicas","category-cirugia","category-cirugia-cardiaca","category-medicina-interna","category-murcia","tag-gines-torres-Martinez","tag-juan-caturla-such","tag-luis-carbonell-meseguer","tag-ramon-arcas-meca","tag-ruben-jara-rubio","tag-tomas-quesada-perez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18033","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18033"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18033\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18033"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18033"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}