{"id":18059,"date":"2002-04-07T00:00:00","date_gmt":"2002-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mucinas-anta%c2%adgenos-lewis-y-fuociltransferasas-implicacion-en-la-progresion-tumoral\/"},"modified":"2002-04-07T00:00:00","modified_gmt":"2002-04-07T00:00:00","slug":"mucinas-anta%c2%adgenos-lewis-y-fuociltransferasas-implicacion-en-la-progresion-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mucinas-anta%c2%adgenos-lewis-y-fuociltransferasas-implicacion-en-la-progresion-tumoral\/","title":{"rendered":"Mucinas, ant\u00edgenos lewis y fuociltransferasas: implicaci\u00f3n en la progresi\u00f3n tumoral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna L\u00f3pez Ferrer <\/strong><\/h2>\n<p>La presencia de alteraciones en los patrones de glicosilaci\u00f3n es uno de los hechos implicados en el proceso de transformaci\u00f3n neopl\u00e1sica de las c\u00e9lulas epiteliales. Los glicoconjugados que se forman en el proceso de o-glicosilaci\u00f3n est\u00e1n asociados de mayoritariamente a las glicoproteinas que forman el moco, siendo las mucinas el componente b\u00e1sico de su composici\u00f3n. estas prote\u00ednas presentan repeticiones en t\u00e1ndem en su secuencia primaria, diferentes para cada mucina y que les confiere el elevado grado de glicosilaci\u00f3n que presentan. Estas secuencias son ricas en serina y treonina, residuos donde se inicia el proceso de o-glicosilaci\u00f3n, de modo que la parte glicos\u00eddica de estas prote\u00ednas puede representar hasta el 80% del su peso molecular. hasta el momento, se han clonado 13 genes de mucinas humanas con patrones de distribuci\u00f3n celular i tisular caracter\u00edsticos. El estudio de su patr\u00f3n de expresi\u00f3n y glicosilaci\u00f3n ha sido uno de los objetivos de esta tesis.  el epitelio g\u00e1strico normal presenta dos poblaciones de c\u00e9lulas mucosecretoras que sintetizan mucinas diferentes: las c\u00e9lulas del epitelio superficial expresan muc5ac en asociaci\u00f3n con ant\u00edgenos lewis de tipo 1 y fut2, mientras que las c\u00e9lulas de las gl\u00e1ndulas expresan muc6, ant\u00edgenos lewis de tipo 2 y fut1. Estos patrones de asociaci\u00f3n se pierden en las primeras etapas de la carcinog\u00e9nesis g\u00e1strica. Algunos de estos patrones anormales tambi\u00e9n han sido detectados durante el desarrollo fetal de la mucosa g\u00e1strica.  con el fin de establecer una asociaci\u00f3n directa entre el patr\u00f3n de expresi\u00f3n de mucinas y su patr\u00f3n de glicosilaci\u00f3n hemos establecido un modelo in vitro utilizando c\u00e9lulas ht-29\/m3 de c\u00e1ncer de colon humano, que expresan muc1, muc5ac, ant\u00edgenos lewis de tipo 1 y fut2 pero no ant\u00edgenos lewis de tipo 2 ni fut1, reproduciendo el patr\u00f3n de expresi\u00f3n de las c\u00e9lulas del epitelio superficial del est\u00f3mago. La transfecci\u00f3n de esta l\u00ednea<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mucinas, ant\u00edgenos lewis y fuociltransferasas: implicaci\u00f3n en la progresi\u00f3n tumoral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mucinas, ant\u00edgenos lewis y fuociltransferasas: implicaci\u00f3n en la progresi\u00f3n tumoral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna L\u00f3pez Ferrer <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Bol\u00f3s Pi Carme De<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Corominas torres <\/li>\n<li>anna Mar\u00eda Bassols teixido (vocal)<\/li>\n<li>Rafael Oriol (vocal)<\/li>\n<li>Jos\u00e9 Garc\u00eda  valero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna L\u00f3pez Ferrer La presencia de alteraciones en los patrones de glicosilaci\u00f3n es uno de los hechos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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