{"id":18071,"date":"2002-04-07T00:00:00","date_gmt":"2002-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-funcion-de-los-receptores-5-ht1a-plaquetarios-por-fentanilo-en-pacientes-sometidos-a-cirugia-cardiovascular\/"},"modified":"2002-04-07T00:00:00","modified_gmt":"2002-04-07T00:00:00","slug":"modulacion-de-la-funcion-de-los-receptores-5-ht1a-plaquetarios-por-fentanilo-en-pacientes-sometidos-a-cirugia-cardiovascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-funcion-de-los-receptores-5-ht1a-plaquetarios-por-fentanilo-en-pacientes-sometidos-a-cirugia-cardiovascular\/","title":{"rendered":"Modulaci\u00f3n de la funci\u00f3n de los receptores 5-ht1a plaquetarios por fentanilo en pacientes sometidos a cirugia cardiovascular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Laureano Delange Segura <\/strong><\/h2>\n<p>Se ha determinado la modulaci\u00f3n de los receptores 5-ht 1a plaquetarios en pacientes sometidos a cirug\u00eda cardiovascular en cuyo protocolo anest\u00e9sico estaba indicado el uso de fentanilo. La caracterizaci\u00f3n de los receptores 5-ht 1a se realiz\u00f3 mediante t\u00e9cnicas de uni\u00f3n de radioligandos usando como marcador 3h-8oh-dpat. La muestra comprendi\u00f3 un total de 83 pacientes, 47 de ellos hombres y 36 mujeres, de los cuales 70 fueron sometidos a cirugia cardiaca y 13 a cirug\u00eda vascular. Fueron incluidos en el estudio pacientes sometidos a cirug\u00eda cardiaca con cec o a cirug\u00eda vascular mayor donde fentanilo fue el principal agente para el mantenimiento de la anestesia. Fueron excluidos aquellos pacientes en tratamiento con f\u00e1rmacos activos sobre el sistema serotonin\u00e9rgico o con antecedentes de enfermedades que cursen con alteraciones del mismo. Se recogieron datos varios sobre la historia cl\u00ednica y anal\u00edticos. los receptores plaquetarios se analizaron en 4 tiempos, previo a la inducci\u00f3n anest\u00e9sica, al comienzo de la cirug\u00eda, previo a cec\/clampaje y al finalizar. los pacientes con patolgo\u00eda cardiovascular presentan valores basales de bmax de los receptores 5-ht1a de las membranas de plaquetas de 2.218 +- 0.47 fmol\/mg de prote\u00ednas. Los concentrados de membranas de plaquetas de voluntarios sanos presentan una bmax de 3.30 +- 0.006 fmol\/mg de prote\u00ednas. los pacientes con patolog\u00eda cardiovascular presentan por tanto una disminuci\u00f3n significativa de un -32.78% en la bmax de los receptores 5-ht 1a de las membranas de las plaquetas respecto a los valores controles. Al finalizar la intervenci\u00f3n los pacientes presentaron un incremento de la bmax de los receptores 5-ht 1a de las membranas de las plaquetas con respecto a los valores basales. Este incremento significativo fue de un 40.47% al considerar la muestra en su totalidad y de un 56.04% al considerar solo a los pacientes sometidos a cirug\u00eda cardiaca. Este incremento no se observ\u00f3 en los<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la funci\u00f3n de los receptores 5-ht1a plaquetarios por fentanilo en pacientes sometidos a cirugia cardiovascular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la funci\u00f3n de los receptores 5-ht1a plaquetarios por fentanilo en pacientes sometidos a cirugia cardiovascular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Laureano Delange Segura <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Inmaculada Bellido Est\u00e9vez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Zarzuela zurita <\/li>\n<li>julio Juan G\u00e1lvez peralta (vocal)<\/li>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez correa (vocal)<\/li>\n<li>pilar S\u00e1nchez gallego (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Laureano Delange Segura Se ha determinado la modulaci\u00f3n de los receptores 5-ht 1a plaquetarios en pacientes sometidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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