{"id":18085,"date":"2002-04-07T00:00:00","date_gmt":"2002-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/propiedades-bioqua%c2%admicas-de-canales-de-k-kcnq\/"},"modified":"2002-04-07T00:00:00","modified_gmt":"2002-04-07T00:00:00","slug":"propiedades-bioqua%c2%admicas-de-canales-de-k-kcnq","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/propiedades-bioqua%c2%admicas-de-canales-de-k-kcnq\/","title":{"rendered":"Propiedades bioqu\u00edmicas de canales de k+ kcnq"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Yus N\u00e1jera <\/strong><\/h2>\n<p>Los canales de potasio de la familia kcnq se hallan mutados en enfermedades humanas como arritmia card\u00edaca (afecta a kcnq1), sordera (kcnq4) o epilepsia (kcnq2 y kcnq3). Juegan un papel capital en el establecimiento del potencial de membrana. Esta memoria describe en primer lugar, el desarrollo de anticuerpos contra los miembros neuronales de la familia, esto es kcnq2, -3 y el \u00faltimo miembro en clonarse, kcnq5, responsables de la corriente m. Estos anticuerpos son espec\u00edficos de subunidad y permiten detectar y purificar las prote\u00ednas. en cuanto a las propiedades bioqu\u00edmicas, las prote\u00ednas presentan una forma a parte de la te\u00f3rica en expresi\u00f3n heter\u00f3loga, asociada a distintos grados de n-glicosilaci\u00f3n, siendo las dos formas de superficie. En tejido nativo presentan una movilidad intermedia, y en todos los casos se localizan en una fracci\u00f3n de membrana altamente soluble.  kcnq2 y kcnq5 se hallan adem\u00e1s en m\u00fasculo esquel\u00e9tico, con otra movilidad y asociadas a una fracci\u00f3n de baja densidad de membrana (asociadas a una balsas de colesterol o ancladas de citoesqueleto).  kcnq3 es capaz de formar heter\u00f3meros con kcnq2 y -5, pero estas dos subunidades no se ensamblan entre si. La potenciaci\u00f3n por heteromerizaci\u00f3n no se debe a un aumento en la s\u00edntesis de las prote\u00ednas. En el desarrollo, kcnq3 permanece constante; kcnq2 se expresa tempranamente y luego da paso a kcnq5. Se cree que esta es la raz\u00f3n por la que la epilepsia asociada a mutaciones en kcnq2 sea de tipo neonatal. En estudios de inmunohistoqu\u00edmica, se observa una expresi\u00f3n ubicua, en el soma y \u00e1rbol dendr\u00edtico proximal.  en segundo lugar, en un cribado de doble h\u00edbrido, se detect\u00f3 una interacci\u00f3n con calmodulina de la regi\u00f3n c-terminal de los canales m. Concretamente se une  a los primeros 200 amino\u00e1cidos. En este segmento son imprescindibles dos subdominios, probablemente alfa-h\u00e9lices, se 40 y 30, separados por un lazo de 130 residuos dispensable. La uni\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Propiedades bioqu\u00edmicas de canales de k+ kcnq<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Propiedades bioqu\u00edmicas de canales de k+ kcnq <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Yus N\u00e1jera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alvaro Villarroel Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Arag\u00f3n rueda <\/li>\n<li>ignacio Vicente-sandoval rodr\u00edguez (vocal)<\/li>\n<li> Vitorica fern\u00e1ndez f. Javier (vocal)<\/li>\n<li>Jos\u00e9 S\u00e1nchez-prieto borja (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Yus N\u00e1jera Los canales de potasio de la familia kcnq se hallan mutados en enfermedades humanas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[56292,5283,56291,56293,6729,56294],"class_list":["post-18085","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-alvaro-villarroel-munoz","tag-carmen-aragon-rueda","tag-eva-yus-najera","tag-ignacio-vicente-sandoval-rodriguez","tag-jose-sanchez-prieto-borja","tag-vitorica-fernandez-f-javier"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=18085"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/18085\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=18085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=18085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=18085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}