{"id":18136,"date":"2002-05-07T00:00:00","date_gmt":"2002-05-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/isotiocianatoazucares-en-la-sintesis-estereocontrolada-de-n-c-y-espiro-nucleosidos\/"},"modified":"2002-05-07T00:00:00","modified_gmt":"2002-05-07T00:00:00","slug":"isotiocianatoazucares-en-la-sintesis-estereocontrolada-de-n-c-y-espiro-nucleosidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/isotiocianatoazucares-en-la-sintesis-estereocontrolada-de-n-c-y-espiro-nucleosidos\/","title":{"rendered":"Isotiocianatoazucares en la sintesis estereocontrolada de n-, c- y espiro-nucle\u00f3sidos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Salameh Bader Abd Al Raem Bader <\/strong><\/h2>\n<p>Esta tesis esta dividida en tres cap\u00edtulos principales:  a,- reacciones de isotiocianatoaz\u00facares con fructosamina.  b,- espironucle\u00f3sidos con anillos 1,3-o, n-heteroc\u00edclicos.  c,- isotiocianatoulosanatos y preparaci\u00f3n de espirotiohidant\u00edonas.  se generaliza la utilizaci\u00f3n del m\u00e9todo dise\u00f1ado en nuestro laboratorio para la preparaci\u00f3n estereoselectiva de 5-hidroxiimidazollidina-2-tionas a trav\u00e9s de la reacci\u00f3n entre furanosilisotiocianatos y derivados de d-fructosamina. la formaci\u00f3n del heterociclo quiral tiene lugar con doble inducci\u00f3n asim\u00e9trica. el grado de estereoselectividad es un poco mejor en los casos en los que el isotiocianato es un derivado de d-ribofuranosa que en aquellos otros en los que es un derivado de d-xilofuranosa.  tambi\u00e9n ha sido estudiada exhaustivamente la deshidrataci\u00f3n en medio \u00e1cido de las imidazolidinas obtenidas anteriormente, lo que ha dado lugar a un m\u00e9todo general para la preparaci\u00f3n estereoselectiva de espiroimidazolidinas con un sustituyente de n-glicosilo y a imidzolinas-2-tionas. La formaci\u00f3n de ambos productos es competitiva. Todos los compuestos obtenidos tienen estructura de n-nucle\u00f3sido, adem\u00e1s de espiro o de aciclo-c nucle\u00f3sido.  tambi\u00e9n se abre un camino adecuado para la formaci\u00f3n estereoselectiva de enlaces de tipo c-c o c-n con participaci\u00f3n del carbono anom\u00e9rico, a trav\u00e9s de las reacciones de espirocetales de la fructopiranosa o de la psicofuranosa con derivados de trimetilsililo. Los compuestos obtenidos se han transformado en espironucle\u00f3sidos o en espiro-c-glic\u00f3sidos de 1,3-o,n-heterociclos a trav\u00e9s de intermedios con estructura de isotiocianato.  asimismo, han sido preparados espironucle\u00f3sidos con anillos de 1,3-o,n-heterociclos a partir de la reacci\u00f3n de aldonolactonas con c-nucle\u00f3filos que contienen grupos trimetilsililo; constituye \u00e9ste un m\u00e9todo para la preparaci\u00f3n estereoselectiva de espiroglic\u00f3sidos de oxazinas a trav\u00e9s de un isotiocianato i<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Isotiocianatoazucares en la sintesis estereocontrolada de n-, c- y espiro-nucle\u00f3sidos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Isotiocianatoazucares en la sintesis estereocontrolada de n-, c- y espiro-nucle\u00f3sidos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Salameh Bader Abd Al Raem Bader <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Fuentes Mota<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel G\u00f3mez guill\u00e9n <\/li>\n<li>Mar\u00eda Valpuesta fern\u00e1ndez (vocal)<\/li>\n<li>julio Delgado mart\u00edn (vocal)<\/li>\n<li> Pradera adr\u00edan M\u00aa angeles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Salameh Bader Abd Al Raem Bader Esta tesis esta dividida en tres cap\u00edtulos principales: a,- reacciones de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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