{"id":18167,"date":"2002-05-07T00:00:00","date_gmt":"2002-05-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/conducta-suicida-ciclo-menstrual-y-gen-del-transporte-de-serotonina\/"},"modified":"2002-05-07T00:00:00","modified_gmt":"2002-05-07T00:00:00","slug":"conducta-suicida-ciclo-menstrual-y-gen-del-transporte-de-serotonina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/conducta-suicida-ciclo-menstrual-y-gen-del-transporte-de-serotonina\/","title":{"rendered":"Conducta suicida, ciclo menstrual y gen del transporte de serotonina"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Severino Dom\u00ednguez Manuel Antonio <\/strong><\/h2>\n<p>Introducci\u00f3n  la investigaci\u00f3n de la relaci\u00f3n entre el intento de suicidio y el ciclo menstrual ha arrojado resultados inconsistentes. Al mismo tiempo, los estudios de asociaci\u00f3n de las variantes al\u00e9licas del polimorfismo 5-httlpr del gen del transportador de serotonina en intentos de suicidio no han alcanzado tampoco conclusiones difinitivas. Los objetivos del presente trabajo tratan de verificar la relaci\u00f3n entre los intentos de suicidio en mujeres y los patrones hormonales del ciclo menstrual (como marcador de estado) por un lado, y el genotipo 5-httlpr (como marcador de rasgo) por otro, as\u00ed como demostrar la interacci\u00f3n entre ambos factores.  material y m\u00e9todo  149 intentos de suicidio en mujeres son comparadas con 117 controles sanas. Se determina la fase del ciclo mesntrual por medio de determinaciones hormonales, y el genotipo 5-httlpr mediante pcr.  resultados  la diferencia entre las distribuciones te\u00f3rica y experimental de intentos de suicidio a lo largo del ciclo se encontr\u00f3 significativa (x2=12.228, g.L.=3, p=0,007), descartando un aumento de las frecuencias observadas de tentativas de suicidio en la fase menstrual, sobre todo a expensas de la mitad del ciclo. La diferencia entre las distribuciones genot\u00edpicas en casos y controles se encontr\u00f3 significativa (x2=6.244, g.L.=2, p=0,0449), destacando una frecuencia del genotipo ll del polimorfismo del promotor del transportador de la sertononina entre las mujeres que han realizado un intento de suicido significativamente menro que la encontrada en el grupo control. La comparaci\u00f3n entre la distribuci\u00f3n de frecuencias genot\u00edpicas en las distintas fases del ciclo en los tres genotipos considerados encontr\u00f3 diferencias significativas (x2=7.038, g.L.=1, p=0,008), con un aumento de las frecuencias observadas de tentativas de suicidio en la fase menstrual m\u00e1s destacado en las mujeres con genotipo ll. La comparaci\u00f3n del genotipo en las menop\u00e1usicas que han realiz<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Conducta suicida, ciclo menstrual y gen del transporte de serotonina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Conducta suicida, ciclo menstrual y gen del transporte de serotonina <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Severino Dom\u00ednguez Manuel Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jeronimo Saiz Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Giner ubago <\/li>\n<li>Jos\u00e9 Luis Ayuso gutierrez (vocal)<\/li>\n<li>tomas Palomo alvarez (vocal)<\/li>\n<li>maximino Lozano suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Severino Dom\u00ednguez Manuel Antonio Introducci\u00f3n la investigaci\u00f3n de la relaci\u00f3n entre el intento de suicidio y el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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