{"id":18198,"date":"2002-08-07T00:00:00","date_gmt":"2002-08-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-de-la-concentracion-de-glucosa-sobre-el-efecto-de-diversos-antiagregantes-en-la-interaccion-plaqueta-pared-vascular\/"},"modified":"2002-08-07T00:00:00","modified_gmt":"2002-08-07T00:00:00","slug":"influencia-de-la-concentracion-de-glucosa-sobre-el-efecto-de-diversos-antiagregantes-en-la-interaccion-plaqueta-pared-vascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-de-la-concentracion-de-glucosa-sobre-el-efecto-de-diversos-antiagregantes-en-la-interaccion-plaqueta-pared-vascular\/","title":{"rendered":"Influencia de la concentraci\u00f3n de glucosa sobre el efecto de diversos antiagregantes en la interacci\u00f3n plaqueta-pared vascular"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pinacfho Vivar Araceli Pilar <\/strong><\/h2>\n<p>Las cifras elevadas de glucosa condicionan la evoluci\u00f3n de las complicaciones vasculares de la diabetes mellitus. En estas complicaciones la activaci\u00f3n de las plaquetas y la disfunci\u00f3n endotelial juegan un papel fundamental, ya que el desequilibrio entre ambos hechos originan la mayor incidencia tromb\u00f3tica en estos pacientes.  el objetivo del presente estudio es valorar si la presencia de altas concentraciones de glucosa modifica el efecto de diversos antiagregantes plaquetarios, como aspirina, ticlopidina o clopidina o clopidogrel, sobre la funci\u00f3n plaquetaria y la interacci\u00f3n plaqueta-subendotelio, as\u00ed como discriminar si esta influencia de la glucosa es mayor cuando afecta a las plaquetas o a las c\u00e9lulas endoteliales.  el estudio se ha realizado in vitro. Las t\u00e9cnicas analizadas han sido: agregometr\u00eda plaquetaria en sangre total, s\u00edntesis de prostaciclina y de \u00f3xido n\u00edtrico en c\u00e9lulas endoteliales humanas en cultivo y perfusi\u00f3n sangu\u00ednea sobre subendotelio producido por las c\u00e9lulas endoteliales en cultivo.  los tres f\u00e1rmacos inhiben la agregaci\u00f3n plaquetaria en sangre total, si bien aspirina lo hace con mayor potencia al utilizar col\u00e1geno como inductor y ticlopidina y clopidogrel lo hace en mayor medida al utilizar adp. Aspirina inhibe la s\u00edntesis de prostaciclina, mientras que los otros dos f\u00e1rmacos no la modifican. La interacci\u00f3n plaqueta-subendotelio es inhibida en mayor medida por ticlopidina y clopidogrel.  altas concentraciones de glucosa producen una hiperactivaci\u00f3n plaquetaria, un descenso de la s\u00edntesis de prostaciclina y de \u00f3xido n\u00edtrico y un incremento de la interacci\u00f3n de las plaquetas con el subendotelio.  en presencia de altas concentraciones de glucosa, aspirina reduce su efecto antiagregante, plaquetario y sobre la interacci\u00f3n plaqueta-subendotelio, as\u00ed como no incrementa la producci\u00f3n de \u00f3xido n\u00edtrico. Ticolpidina y clopidogrel no modifican su efecto en presencia de altas concentrac<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia de la concentraci\u00f3n de glucosa sobre el efecto de diversos antiagregantes en la interacci\u00f3n plaqueta-pared vascular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia de la concentraci\u00f3n de glucosa sobre el efecto de diversos antiagregantes en la interacci\u00f3n plaqueta-pared vascular <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pinacfho Vivar Araceli Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/07\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Cruz Cortes Jos\u00e9 Pedro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Smith agreda Jos\u00e9 Mar\u00eda <\/li>\n<li>Luis Lafuente nu\u00f1ez (vocal)<\/li>\n<li>Francisco Javier Galiana Martinez (vocal)<\/li>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez correa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pinacfho Vivar Araceli Pilar Las cifras elevadas de glucosa condicionan la evoluci\u00f3n de las complicaciones vasculares de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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